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NCT05379218
RIC in HIE: A Safety and Feasibility Trial
NA trial testing Remote Ischemic Conditioning in Hypoxic-Ischemic Encephalopathy in 32 participants. Completed in 5 February 2024.
5 February 2024
Quick facts
| Lead sponsor | The Hospital for Sick Children |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | other |
| Enrollment | 32 |
| Start date | 17 January 2022 |
| Primary completion | 5 February 2024 |
| Estimated completion | 5 February 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Remote Ischemic Conditioning
Conditions studied
- Hypoxic-Ischemic Encephalopathy — all drugs for Hypoxic-Ischemic Encephalopathy →
Sponsor
The Hospital for Sick Children
Who can join
Eligibility, any sex, with Hypoxic-Ischemic Encephalopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Remote Ischemic Conditioning has never been studied in neonates with HIE. However, RIC has been studied in animal models of perinatal asphyxia and has shown encouraging results. In neonatal rats with HIE, RIC is associated with reduced sensory motor deficits compared to non-RIC, and repeated cycles in three consecutive days is superior to a single treatment. In piglets, four cycles of 10 minutes of bilateral hindlimb ischemia immediately after bilateral common carotid occlusion results in reduced cell death in the periventricular white matter and internal capsule. These preclinical studies support the hypothesis that RIC may be beneficial in infants with HIE.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy.
Ranjan AK, Gulati A. · · 2023 · cited 41× · PMID 37892791 · DOI 10.3390/jcm12206653
Verify or expand the search:
- PubMed search for NCT05379218
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Remote Ischemic Conditioning
Trials testing the same drug.
- NCT07531394 — Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Myocardial Injury Following Acute Ischemic St · Phase 3 · not yet recruiting
- NCT06082583 — The Efficacy of Combination of Traditional Tibetan and Remote Ischemic Conditioning on High Altitude Polycythemia · Phase 2, PHASE3 · unknown
- NCT05653505 — Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Atherosclerotic Stenosis · not yet recruiting
- NCT04659460 — RIC as an Adjunct Therapy for Severe COVID-19 Disease: a Prospective Randomized Pilot Study · NA · unknown
- NCT04266639 — Rheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic Stroke · NA · completed
Other recruiting trials for Hypoxic-Ischemic Encephalopathy
Currently open trials in the same condition.
- NCT07020091 — Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest · active not recruiting
- NCT05610085 — A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures · Phase 2 · recruiting
- NCT03657394 — Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries · NA · active not recruiting
- NCT03682042 — Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up · NA · recruiting
- NCT05568264 — Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit · NA · recruiting
Other The Hospital for Sick Children trials
Trials by the same sponsor.
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- NCT07508826 — AI-assisted Endotracheal Intubation · NA · not yet recruiting
- NCT07345819 — Dexamethasone vs. Placebo in Children and Youth Hospitalized for Orbital Cellulitis · NA · not yet recruiting
- NCT07497178 — MRgFUS for Childhood Epilepsy · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05379218 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Hospital for Sick Children
- Last refreshed: 7 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05379218.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing