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NCT03657394: CORDMILK
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries
NA trial testing Umbilical cord milking in Hypoxic-Ischemic Encephalopathy in 3,442 participants. Participants enrolled and being followed up; not accepting new ones.
1 September 2025
Quick facts
| Lead sponsor | Nemours Children's Clinic |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 3,442 |
| Start date | 17 October 2022 |
| Primary completion | 1 September 2025 |
| Estimated completion | 28 June 2026 |
| Sites | 9 locations across India |
Drugs / interventions tested
- Umbilical cord milking
Conditions studied
- Hypoxic-Ischemic Encephalopathy — all drugs for Hypoxic-Ischemic Encephalopathy →
- Birth Asphyxia — all drugs for Birth Asphyxia →
Sponsor
Nemours Children's Clinic
Who can join
Adults 35 Weeks to 42 Weeks, any sex, with Hypoxic-Ischemic Encephalopathy or Birth Asphyxia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators will conduct a study on non-vigorous infants at birth to determine if umbilical cord milking (UCM) results in lower rate of moderate to severe hypoxic ischemic encephalopathy (HIE) or death than early clamping and for infants who are non-vigorous at birth and need immediate resuscitation.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
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Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.
Rabe H, Gyte GM, Díaz-Rossello JL, Duley L. · · 2019 · cited 156× · PMID 31529790 · DOI 10.1002/14651858.cd003248.pub4 -
Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy.
Ranjan AK, Gulati A. · · 2023 · cited 41× · PMID 37892791 · DOI 10.3390/jcm12206653 -
Autologous cord blood in children with cerebral palsy: a review.
Boruczkowski D, Pujal JM, Zdolińska-Malinowska I. · · 2019 · cited 14× · PMID 31100943 · DOI 10.3390/ijms20102433 -
Umbilical cord milking-benefits and risks.
Koo J, Kilicdag H, Katheria A. · · 2023 · cited 13× · PMID 37144151 · DOI 10.3389/fped.2023.1146057 -
Two-Year Outcomes of Umbilical Cord Milking in Nonvigorous Infants: A Secondary Analysis of the MINVI Randomized Clinical Trial.
Katheria AC, El Ghormli L, Clark E, Yoder B, et al · · 2024 · cited 3× · PMID 38949814 · DOI 10.1001/jamanetworkopen.2024.16870 -
CORDMILK: Umbilical Cord Milking versus Early Cord Clamping on short-and long-term outcomes in neonates who are non-vigorous at birth-study protocol of a multi-center, cluster-randomized, crossover-controlled trial.
Yogeshkumar S, Vernekar SS, Dhaded SM, Talekar K, et al · · 2025 · PMID 41250198 · DOI 10.1186/s13063-025-09197-8
Verify or expand the search:
- PubMed search for NCT03657394
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Umbilical cord milking
Trials testing the same drug.
- NCT06240715 — Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm · NA · recruiting
- NCT06090968 — Umbilical Cord Milking Versus Immediate Cord Clamping in Full Term Neonates (≥ 37 Weeks) Requiring Resuscitation · NA · completed
- NCT05922488 — Effect of Umbilical Cord Milking Versus Clamping in Preterms on Cerebral Oxygenation and Ductus Arteriosus Closure · NA · completed
- NCT03983902 — Placental Transfusion Methods and Stem Cells · NA · unknown
- NCT03859037 — Effect of Umbilical Cord Milking on Transition of Preterm Babies During Resuscitation · NA · unknown
Other recruiting trials for Hypoxic-Ischemic Encephalopathy
Currently open trials in the same condition.
- NCT07020091 — Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest · active not recruiting
- NCT05610085 — A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures · Phase 2 · recruiting
- NCT03682042 — Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up · NA · recruiting
- NCT05568264 — Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Unit · NA · recruiting
- NCT05361070 — Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy · active not recruiting
Other Nemours Children's Clinic trials
Trials by the same sponsor.
- NCT06616818 — DASH Diet Intervention for Systemic Hypertension in Adolescents · NA · withdrawn
- NCT07218588 — Sanctuary Farm Prescription in Adolescents · NA · recruiting
- NCT06406621 — Pilot Trial Assessing the Effectiveness of Laser Hair Depilation on Pilonidal Disease Recurrence in Patients With Darker · NA · recruiting
- NCT07154667 — Evaluation of the Auryzon™ EAR 2.0 System in Ear Reconstruction · NA · recruiting
- NCT07212049 — Ultrasound Use to Measure Magnetically Controlled Growing Rods · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03657394 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nemours Children's Clinic
- Last refreshed: 13 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03657394.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing