Last reviewed · How we verify
NCT05377957: PROQEM
Prospective Registration Of Patient Data and Quality of Life in Eye Melanoma Patients
trial testing Quality of life questionnaires in Uveal Melanoma in 500 participants. Participants enrolled and being followed up; not accepting new ones.
1 April 2028
Quick facts
| Lead sponsor | Leiden University Medical Center |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 5 March 2019 |
| Primary completion | 1 April 2028 |
| Estimated completion | 1 April 2031 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Quality of life questionnaires
- Discrete choice experiment
- Shared decision-making analysis
- Impact of side-effects analysis
Conditions studied
- Uveal Melanoma — all drugs for Uveal Melanoma →
Sponsor
Leiden University Medical Center
Who can join
18 and older, any sex, with Uveal Melanoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
PROQEM is a prospective cohort study among patients diagnosed with uveal melanoma to assess quality of life before and in the first five years after treatment.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Choroidal melanoma patient views on the importance of treatment characteristics and outcomes, and physicians' information provision in the Netherlands.
Shirzada A, Pieterse AH, Vlug L, Luyten GPM, et al · · 2025 · cited 1× · PMID 40263738 · DOI 10.1111/aos.17505 -
Uveal melanoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.
Piperno-Neumann S, Angi M, Ascierto PA, Baurain JF, et al · · 2026 · PMID 42020098 · DOI 10.1016/j.esmoop.2026.106888
Verify or expand the search:
- PubMed search for NCT05377957
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Uveal Melanoma
Currently open trials in the same condition.
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- NCT06070012 — Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma · Phase 2 · recruiting
- NCT06932757 — Adjuvant Quisinostat in High-Risk Uveal Melanoma · Phase 2 · recruiting
- NCT06805825 — A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Expres · Phase 1 · recruiting
- NCT06519266 — PHP in Combination With IPI1/NIVO3 Compared to IPI3/NIVO1 Only in Patients With Uveal Melanoma Liver Metastases · Phase 3 · recruiting
Other Leiden University Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05377957 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Leiden University Medical Center
- Last refreshed: 15 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05377957.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing