NCT05373771: SCIENCE

Sickle Cell Improvement: Enhancing Care in the Emergency Department

Recruiting now NA Last updated 14 August 2023

What this trial tests

NA trial testing Care pathway in Sickle Cell Crisis in 5,328 participants. Currently enrolling.

Timeline

1 September 2021

Primary endpoint
31 August 2026

31 August 2027

Quick facts

Lead sponsor	Medical College of Wisconsin
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	5,328
Start date	1 September 2021
Primary completion	31 August 2026
Estimated completion	31 August 2027
Sites	1 location across United States

Drugs / interventions tested

• Care pathway

Conditions studied

• Sickle Cell Crisis — all drugs for Sickle Cell Crisis →

Sponsor

Medical College of Wisconsin

Who can join

Under 18, any sex, with Sickle Cell Crisis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 36,000 children in the United States, approximately 90% of whom are Black. The disease is characterized by recurrent, severe pain crises which result in high rates of emergency department visits and hospitalizations, and decreased quality of life. The National Heart, Lung and Blood Institute, as well as the American Society of Hematology, have endorsed pain management guidelines regarding the timeliness of care for children presenting with these acute pain crises. These evidence-based guidelines are infrequently followed, resulting in increased pain and hospitalizations. In additional to other barriers to following the guideline, structural racism has been proposed as a significant contributor and the New England Journal of Medicine recently called for the institution of SCD-specific pain management protocols to combat structural racism and reduce time to opioid administration. The investigators' long-term goal is to improve the care and health outcomes of children with acute painful vaso-occlusive crisis treated in the emergency department. The overall aim of the investigators is to test a care pathway using multifaceted implementation strategies to increase guideline adherent care for children in the emergency department with acute painful vaso-occlusive crisis.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.