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NCT07228208
Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes
NA trial testing MitoQ (mitoquinol mesylate) in Type 2 Diabetes (T2DM) in 40 participants. Not yet recruiting.
30 June 2031
Quick facts
| Lead sponsor | Medical College of Wisconsin |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 40 |
| Start date | 1 September 2026 |
| Primary completion | 30 June 2031 |
| Estimated completion | 31 December 2031 |
| Sites | 1 location across United States |
Drugs / interventions tested
- MitoQ (mitoquinol mesylate) — full drug profile →
- Placebo
Conditions studied
- Type 2 Diabetes (T2DM) — all drugs for Type 2 Diabetes (T2DM) →
- Endothelial Dysfunction — all drugs for Endothelial Dysfunction →
Sponsor
Medical College of Wisconsin
Who can join
Adults 18 to 80, any sex, with Type 2 Diabetes (T2DM) or Endothelial Dysfunction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Exaggerated blood pressure responses to exercise in individuals with Type 2 Diabetes significantly increase the risk of heart attack, stroke, and cardiovascular death, while also limiting exercise capacity and therapeutic benefits of physical activity. This research will determine whether impaired blood vessel function and excessive cellular damage from oxygen-containing molecules cause these dangerous blood pressure responses during exercise. The findings will establish whether targeting cellular antioxidant systems represents a new therapeutic approach to improve exercise tolerance and reduce cardiovascular risk in t Americans living with diabetes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07228208
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of MitoQ (mitoquinol mesylate)
Trials testing the same drug.
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Other recruiting trials for Type 2 Diabetes (T2DM)
Currently open trials in the same condition.
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- NCT07156370 — Salivary Cortisol and Hypercortisolism in Type 2 Diabetes · recruiting
- NCT07286500 — "Sexual Activity and Hypoglycemia Risk in Adults With Type 1 or Type 2 Diabetes Using Insulin Therapy and Continuous Glu · recruiting
- NCT07094529 — Personalized Hypoglycemia Outpatient Treatment - a Feasibility Study · NA · recruiting
- NCT07064486 — A Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia · Phase 3 · recruiting
Other Medical College of Wisconsin trials
Trials by the same sponsor.
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- NCT06795360 — Weight Changes After Incretin-mimetics · NA · not yet recruiting
- NCT07298460 — Stimulation-based Therapy to Improve Balance in DCM · Phase 1, PHASE2 · not yet recruiting
- NCT07434544 — Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D) · NA · not yet recruiting
- NCT07335328 — Fully Human Bispecific Anti-CD20, Anti-CD19 CAR T Cells for Patients With Relapsed and/or Refractory B Cell Malignancies · Phase 1 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07228208 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical College of Wisconsin
- Last refreshed: 14 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07228208.
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