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NCT05373082: MODIFSPA2
Identification of Modifying Factors in Hereditary Spastic Paraplegia
trial testing questionnaire completion in Hereditary Spastic Paraplegia in 311 participants. Completed in 3 October 2023.
3 October 2023
Quick facts
| Lead sponsor | Assistance Publique - Hôpitaux de Paris |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 311 |
| Start date | 4 October 2022 |
| Primary completion | 3 October 2023 |
| Estimated completion | 3 October 2023 |
| Sites | 1 location across France |
Drugs / interventions tested
- questionnaire completion
Conditions studied
- Hereditary Spastic Paraplegia — all drugs for Hereditary Spastic Paraplegia →
Sponsor
Assistance Publique - Hôpitaux de Paris — full company profile →
Who can join
18 and older, any sex, with Hereditary Spastic Paraplegia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A first questionnaire - MODIFSPA conducted in 2014 - identified several environmental factors influencing spasticity in HSP: cold, fatigue, and especially physical activity. In order to improve the care of patients with HSP, The investigator team are looking to deepen the knowledge on physical exercises relieving spasticity as well as to better know the frequency of symptoms requiring additional medical care: fatigue and vesico-sphincter disorders. A new questionnaire was therefore created to collect additional information to optimize the care of patients with HSP.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Hereditary spastic paraplegias: When to expect bladder dysfunction a genetic and urodynamic study.
Lallemant-Dudek P, Guillaud-Bataille M, Hentzen C, Joussain C, et al · · 2025 · cited 1× · PMID 39704400 · DOI 10.1111/ene.70003
Verify or expand the search:
- PubMed search for NCT05373082
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of questionnaire completion
Trials testing the same drug.
- NCT03999034 — XO as a Screening Test of Cognitive Impairment in Multiple Sclerosis · NA · unknown
Other recruiting trials for Hereditary Spastic Paraplegia
Currently open trials in the same condition.
- NCT07478172 — Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease · NA · recruiting
- NCT07417943 — Neuromodulation to Enhance Motor Function in HSP · NA · recruiting
- NCT06936163 — A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP · recruiting
- NCT06844734 — A Prospective Cohort Study of ITB Treatment for HSP · recruiting
- NCT06478238 — Calcium Folinate Treatment of Spastic Paraplegia 56 · EARLY_PHASE1 · recruiting
Other Assistance Publique - Hôpitaux de Paris trials
Trials by the same sponsor.
- NCT07443436 — Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants · Phase 2 · not yet recruiting
- NCT07499492 — Red Blood Cell Transfusion to Optimize Extubation · NA · not yet recruiting
- NCT07379918 — Real-life Evaluation of Endopredict® in Early HR+/HER2- Breast Cancer · recruiting
- NCT07473869 — Smartphone Application for Automated Measurement of Capillary Refill Time (CRT) · not yet recruiting
- NCT07505394 — Efficacy of a Prediction Model-based Algorithm to PREVENT Drug-induced Impulse Control Disorders in Parkinson's Disease · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05373082 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Assistance Publique - Hôpitaux de Paris
- Last refreshed: 31 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05373082.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing