Adults 5 to 25, any sex, with Autism Spectrum Disorder. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
The Effects of rTMS on Reciprocal Social AwarenessPrimary· at baseline and 5 weeks of rTMS
Social Responsiveness Scale, Second Edition (SRS-2), Parent/Caregiver form; 65 items scored 0-3; total raw score range 0-195. Higher scores = greater social impairment. This study reports raw totals (not T-scores). Instrument: SRS-2
Baseline
Group
Value
95% CI
Left IPL Stimulation
68
± 9.823
Right IPL Stimulation
79.667
± 14.624
Week 5
Group
Value
95% CI
Left IPL Stimulation
64.2
± 5.310
Right IPL Stimulation
74
± 16.505
The Effects of rTMS on Reciprocal Rigid Patterns of BehaviorPrimary· at baseline and 5 weeks of rTMS
Repetitive Behavior Scale-Revised (RBS-R); 43 items scored 0-3; total raw score range 0-129. Higher scores = more severe restricted/repetitive behaviors. We report total raw scores.
Baseline
Group
Value
95% CI
Left IPL Stimulation
75.8
± 11.212
Right IPL Stimulation
86.667
± 14.334
Week 5
Group
Value
95% CI
Left IPL Stimulation
75.4
± 12.260
Right IPL Stimulation
81.333
± 12.879
The Effect of rTMS on Verbal FluencySecondary· at baseline and 5 weeks of rTMS
Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency; scores converted to age-normed scaled scores (mean 10, SD 3). Higher scores = better verbal fluency/executive function. We report the Total Correct scaled score per the manual.
Baseline
Group
Value
95% CI
Left IPL Stimulation
5.8
± 3.834
Right IPL Stimulation
8.5
± 7.778
Week 5
Group
Value
95% CI
Left IPL Stimulation
5.6
± 2.793
Right IPL Stimulation
9
± 9.899
The Effects of rTMS on Executive Function Using Flanker TaskSecondary· at baseline and 5 weeks of rTMS
NIH Toolbox Flanker Inhibitory Control and Attention; Age-Adjusted Standard Scores (mean 100, SD 15) reported. Higher scores = better inhibitory control/attention.
Baseline
Group
Value
95% CI
Left IPL Stimulation
66.8
± 14.025
Right IPL Stimulation
86
± 22.996
Week 5
Group
Value
95% CI
Left IPL Stimulation
71.4
± 16.742
Right IPL Stimulation
83.833
± 24.555
The Effects of rTMS on Executive FunctionSecondary· at baseline and 5 weeks of rTMS
Autism spectrum disorder (ASD) encompasses a range of limitations in reciprocal social and communicative milestones, as well as restrictive and/or repetitive patterns of behavior which lead to significant functional challenges impacting individuals throughout their lifespan. There are major shortcomings in the existing pharmacological interventions; they are of limited efficacy, target a subset of problematic behaviors, and fail to improve social cognition. To overcome these limitations and improve outcomes, the investigators study the use of neurostimulation to mitigate the social and cognitive manifestations of ASD.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Other recruiting trials for Autism Spectrum Disorder
Currently open trials in the same condition.
NCT07324057 — The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavi
· NA
· recruiting
NCT07493096 — Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disor
· recruiting
NCT07505290 — Efficacy of the Korean PEERS® for Preschoolers (PEERS®-PS-K) Social Skills Intervention: A Randomized Controlled Trial f
· NA
· active not recruiting
NCT07524192 — A Self-Instructional Online Program for Early Childhood and Elementary Teachers Supporting Autistic Children and Childre
· NA
· recruiting
NCT07432776 — Effect of an 8-Week Pickleball Program for Adults With Autism: A Feasibility Trial With a Delayed-Control Design
· EARLY_PHASE1
· recruiting
Other Christiana Care Health Services trials
Trials by the same sponsor.
NCT06807684 — Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigatin
· NA
· recruiting
NCT06268431 — Oxytocin Rest to Reduce Cesarean Delivery
· NA
· recruiting
NCT05232994 — Metformin and Esomeprazole For Preterm Pre-eclampsia
· Phase 1
· unknown
NCT05547139 — Impact of Extended CPAP on Bronchopulmonary Dysplasia
· NA
· completed
NCT04739683 — Cervical Ripening With Foley Bulb Versus Dilapan-S at Home
· NA
· withdrawn
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Christiana Care Health Services
Last refreshed: 26 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05371912.