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NCT06268431: ORCA
Oxytocin Rest to Reduce Cesarean Delivery
NA trial testing Oxytocin rest in Prolonged Labor in 350 participants. Currently enrolling.
15 February 2026
Quick facts
| Lead sponsor | Christiana Care Health Services |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 350 |
| Start date | 19 March 2024 |
| Primary completion | 15 February 2026 |
| Estimated completion | 15 March 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Oxytocin rest
Conditions studied
- Prolonged Labor — all drugs for Prolonged Labor →
- Failed Induction — all drugs for Failed Induction →
- Labor Dystocia — all drugs for Labor Dystocia →
Sponsor
Christiana Care Health Services — full company profile →
Who can join
Adults 18 to 55, female only, with Prolonged Labor or Failed Induction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Prolonged labor is usually managed with continuous oxytocin infusion. "Oxytocin rest" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. "Oxytocin rest" is performed on labor and delivery units across the United States. Yet, there is no randomized or prospective data to support the practice. The purpose of this study is to assess whether oxytocin rest of 60 minutes in patients with prolonged labor reduces risk for cesarean delivery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06268431
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Prolonged Labor
Currently open trials in the same condition.
- NCT06636149 — Maternal Maneuvers During Prolonged Labor · NA · recruiting
Other Christiana Care Health Services trials
Trials by the same sponsor.
- NCT06807684 — Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigatin · NA · recruiting
- NCT05232994 — Metformin and Esomeprazole For Preterm Pre-eclampsia · Phase 1 · unknown
- NCT05547139 — Impact of Extended CPAP on Bronchopulmonary Dysplasia · NA · completed
- NCT04739683 — Cervical Ripening With Foley Bulb Versus Dilapan-S at Home · NA · withdrawn
- NCT05209269 — Work of Breathing in Term Infants · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06268431 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Christiana Care Health Services
- Last refreshed: 17 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06268431.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing