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NCT05362188
Topical Nicotinamide in Treatment of DLE
EARLY_PHASE1 trial testing Nicotinamide Topical in Discoid Lupus Erythematosus in 60 participants. Completed in 30 September 2022.
1 September 2022
Quick facts
| Lead sponsor | Al-Azhar University |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 March 2022 |
| Primary completion | 1 September 2022 |
| Estimated completion | 30 September 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Nicotinamide Topical — full drug profile →
Conditions studied
- Discoid Lupus Erythematosus — all drugs for Discoid Lupus Erythematosus →
Sponsor
Al-Azhar University
Who can join
Adults 18 to 65, any sex, with Discoid Lupus Erythematosus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cutaneous lupus erythematosus (CLE) is lupus affecting the skin. In this autoimmune disease, the body's immune system attacks healthy skin. There are 3 main types: Acute cutaneous lupus, Subacute cutaneous lupus, and Chronic cutaneous lupus ("discoid lupus"). Lupus most often appears between the ages of 20 and 50 years; it affects women more than men, and it may happen more in patients with a family history of lupus or other autoimmune diseases.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond.
Camillo L, Zavattaro E, Savoia P. · · 2025 · cited 4× · PMID 40005371 · DOI 10.3390/medicina61020254
Verify or expand the search:
- PubMed search for NCT05362188
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Discoid Lupus Erythematosus
Currently open trials in the same condition.
- NCT06261021 — Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects with Discoid Lupus Erythematosus · Phase 2 · recruiting
Other Al-Azhar University trials
Trials by the same sponsor.
- NCT06489327 — Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery · NA · recruiting
- NCT07327918 — Effect of Epidural Needle Injection on Catheter Placement Success During Painless Labour · Phase 3 · not yet recruiting
- NCT07500194 — Quad Helix vs RME for Posterior Cross-bite in Egyptian Children · NA · not yet recruiting
- NCT07360756 — Ultrasonographic ONSD as a Predictor of PDPH in Spinal Anesthesia for Cesarean Delivery · not yet recruiting
- NCT07343570 — Comparison of Quadratus Lumborum and Combined Groin Nerve Blocks for Postoperative Analgesia After Open Inguinal Hernia · Phase 3 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05362188 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Al-Azhar University
- Last refreshed: 25 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05362188.
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