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NCT05361291
Evaluation of the Effect of Adding Dexamethasone to 2% Lidocaine
NA trial testing Lidocaine Hydrochloride in Pulpitis - Irreversible in 124 participants. Completed in 25 August 2021.
25 August 2021
Quick facts
| Lead sponsor | Jamia Millia Islamia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 124 |
| Start date | 1 February 2020 |
| Primary completion | 25 August 2021 |
| Estimated completion | 25 August 2021 |
| Sites | 1 location across India |
Drugs / interventions tested
- Lidocaine Hydrochloride (Lidocaine Hydrochloride) — full drug profile →
Conditions studied
- Pulpitis - Irreversible — all drugs for Pulpitis - Irreversible →
Sponsor
Jamia Millia Islamia
Who can join
Adults 18 to 59, any sex, with Pulpitis - Irreversible. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized, double-blind clinical trial aimed at the evaluation of the effect of adding dexamethasone to 2% lidocaine, given as inferior alveolar nerve block in the endodontic management of symptomatic irreversible pulpitis. One hundred and twenty four patients received one of the three IANB injections before the endodontic treatment: 2% lidocaine with 1:80 000 epinephrine; 2% lidocaine with 1:80 000 epinephrine mixed with 2mg dexamethasone; and plain 2% lidocaine mixed with 2mg dexamethasone. The anesthetia was considered successful if the patients experienced no pain or faint/weak/mild pain during root canal access preparation and instrumentation (HP VAS score \<55 mm). The effect of intraligamentary injections on maximum heart rates was also recorded.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Erratum: Addendum: Addition of 2 mg dexamethasone to improve the anesthetic efficacy of 2% lidocaine with 1:80,000 epinephrine administered for inferior alveolar nerve block to patients with symptomatic irreversible pulpitis in the mandibular molars: a randomized double-blind cli
Aggarwal V, Ahmad T, Singla M, Gupta A, et al · · 2023 · PMID 36819608 · DOI 10.17245/jdapm.2023.23.1.54
Verify or expand the search:
- PubMed search for NCT05361291
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Lidocaine Hydrochloride
Trials testing the same drug.
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- NCT07079449 — Comparison of Lidocaine, Mepivacaine, and Dry Needling in Myofascial Pain Syndrome · NA · completed
- NCT06662318 — Perioperative Pain Management for Lumbar Spine Surgery · NA · completed
- NCT06319534 — Stellate Ganglion Block in Bulbar Palsy · NA · completed
- NCT06225076 — Efficacy of Stellate Ganglion Block in Dysphagic Patients With Bulbar Palsy After Ischemic Stroke · NA · withdrawn
Other recruiting trials for Pulpitis - Irreversible
Currently open trials in the same condition.
- NCT07245004 — Effect of Cryotherapy on Postoperative Pain for Pulpotomy · EARLY_PHASE1 · active not recruiting
- NCT07340606 — The Role of the Pre-operative Condition and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full · NA · recruiting
- NCT07375576 — Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis · NA · recruiting
- NCT07306533 — Effect of Menstrual Phase on the Anesthetic Efficacy · NA · recruiting
- NCT07130214 — The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy · active not recruiting
Other Jamia Millia Islamia trials
Trials by the same sponsor.
- NCT07532200 — SCN9A Gene Expression and Inflammatory Cytokines · not yet recruiting
- NCT07306533 — Effect of Menstrual Phase on the Anesthetic Efficacy · NA · recruiting
- NCT07012382 — Single Gene Polymorphism and the Success Rate of Inferior Alveolar Nerve Block · NA · completed
- NCT06201871 — Effect of Alcohol Consumption on the Success Rates · NA · unknown
- NCT06186921 — Intraligamentary Injections and Post-endodontic Pain · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05361291 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Jamia Millia Islamia
- Last refreshed: 5 May 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05361291.
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