Last reviewed · How we verify
NCT05359250: MIDAVAX
Myocardial Injury and Dysfunction Associated With COVID-19 Vaccination
trial in Myocardial Injury in 10 participants. Completed in 30 December 2024.
30 December 2024
Quick facts
| Lead sponsor | University of Colorado, Denver |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 12 May 2021 |
| Primary completion | 30 December 2024 |
| Estimated completion | 30 December 2024 |
| Sites | 1 location across United States |
Conditions studied
- Myocardial Injury — all drugs for Myocardial Injury →
- COVID-19 — all drugs for COVID-19 →
- Vaccine Reaction — all drugs for Vaccine Reaction →
Sponsor
University of Colorado, Denver
Who can join
18 and older, any sex, with Myocardial Injury or COVID-19. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overall goal of the study is to investigate the characteristics and potential mechanisms responsible for myocardial injury and dysfunction in patients after COVID-19 vaccination. Cardiac damage will be assessed with cardiac MRI and endomyocardial biopsy (EmBx) histopathology. Myocardial gene expression will be measured in RNA extracted from EmBxs mRNA abundance compared to nonfailing and failing control hearts.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Vaccination-Associated Myocarditis and Myocardial Injury.
Altman NL, Berning AA, Mann SC, Quaife RA, et al · · 2023 · cited 24× · PMID 37167355 · DOI 10.1161/circresaha.122.321881 -
Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination.
Altman NL, Berning AA, Saxon CE, Adamek KE, et al · · 2023 · cited 18× · PMID 36281440 · DOI 10.1016/j.jacbts.2022.08.005 -
Myocardial Injury and Altered Gene Expression Associated with SARS-CoV-2 Infection or mRNA Vaccination
Altman NL, Berning A, Saxon CE, Adamek KE, et al · · 2022 · DOI 10.2139/ssrn.4137991
Verify or expand the search:
- PubMed search for NCT05359250
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other University of Colorado, Denver trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05359250 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Colorado, Denver
- Last refreshed: 4 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05359250.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing