Last reviewed · How we verify
NCT05357170
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
trial testing Human feces collection in Sepsis, Trauma Injury in 468 participants. Currently enrolling.
31 May 2027
Quick facts
| Lead sponsor | University of Florida |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 468 |
| Start date | 21 June 2022 |
| Primary completion | 31 May 2027 |
| Estimated completion | 31 May 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Human feces collection
Conditions studied
- Sepsis, Trauma Injury — all drugs for Sepsis, Trauma Injury →
Sponsor
University of Florida
Who can join
Adults 18 to 110, any sex, with Sepsis, Trauma Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after surgical intensive care admission is understudied but may be responsible for persistent systemic inflammation clinically observed in surgical intensive care patients. Therefore, the objective of this project is to investigate the oral and gut microbiome after the acute phase of sepsis, severe trauma injury, cardiopulmonary bypass, and major vascular surgery to compare with 108 age-matched healthy population controls
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Gut mycobiome dysbiosis after sepsis and trauma.
Park G, Munley JA, Kelly LS, Kannan KB, et al · · 2024 · cited 22× · PMID 38212826 · DOI 10.1186/s13054-023-04780-4 -
Persistence and Sexual Dimorphism of Gut Dysbiosis and Pathobiome after Sepsis and Trauma.
Munley JA, Park G, Kelly LS, Kannan KB, et al · · 2024 · cited 3× · PMID 38864230 · DOI 10.1097/sla.0000000000006385
Verify or expand the search:
- PubMed search for NCT05357170
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other University of Florida trials
Trials by the same sponsor.
- NCT03429413 — Maximizing HPV Vaccination: Real-time Reminders, Guidance, and Recommendations - Part 4: Feasibility Trial · NA · not yet recruiting
- NCT06127550 — taVNS for Letter Learning in Dyslexia · NA · suspended
- NCT07507214 — Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athl · Phase 2, PHASE3 · not yet recruiting
- NCT07492316 — RNA-lipid Particle (RNA-LP) Vaccines for Recurrent/Progressive Medulloblastoma (MB) · Phase 1 · not yet recruiting
- NCT06670794 — Using Ecological Momentary Data to Inform a Web Intervention for Romantic Partners Concerned About Their Loved Ones' Dri · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05357170 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Florida
- Last refreshed: 12 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05357170.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing