Who is sponsoring NCT05356546?

NCT05356546 is sponsored by Medtronic Cardiac Rhythm and Heart Failure.

What condition does NCT05356546 study?

NCT05356546 studies Cardiac Disease, Healing Surgical Wounds.

Is NCT05356546 still recruiting?

NCT05356546 is currently completed. Last updated 24 August 2023.

Last reviewed 2023-08-24 · How we verify

NCT05356546

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

TYRX™ Pocket Health Study

Completed Last updated 24 August 2023

What this trial tests

trial testing Study-required procedures include: tissue collection from device capsule, questionnaire collection, and photo collection in Cardiac Disease in 36 participants. Completed in 6 July 2023.

Timeline

31 May 2022

Primary endpoint
6 July 2023

6 July 2023

Quick facts

Lead sponsor	Medtronic Cardiac Rhythm and Heart Failure
Status	Completed
Study type	OBSERVATIONAL
Enrollment	36
Start date	31 May 2022
Primary completion	6 July 2023
Estimated completion	6 July 2023
Sites	9 locations across Italy, Canada, United States, United Kingdom

Drugs / interventions tested

Study-required procedures include: tissue collection from device capsule, questionnaire collection, and photo collection

Conditions studied

Cardiac Disease — all drugs for Cardiac Disease →
Healing Surgical Wounds — all drugs for Healing Surgical Wounds →

Sponsor

Medtronic Cardiac Rhythm and Heart Failure — full company profile →

Who can join

18 and older, any sex, with Cardiac Disease or Healing Surgical Wounds. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Medtronic, Inc. is sponsoring the TYRX™ Pocket Health Study to evaluate the histological and morphometric parameters of the device capsule in participants who underwent a cardiovascular implantable electronic device (CIED) procedure with a TYRX™ Absorbable Antibacterial Envelope and are returning for a CIED replacement procedure.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

An Absorbable Antibacterial Envelope Promotes Development of a Healthy Device Pocket: Results of the TYRX Pocket Health Study.
Philippon F, Ladich E, Virmani R, Ip JE, et al · · 2025 · cited 2× · PMID 40521692 · DOI 10.1111/jce.16766
Standard Poster Abstracts for the 17th Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions
· 2025

Verify or expand the search:

Other recruiting trials for Cardiac Disease

Currently open trials in the same condition.

NCT07532174 — Efferon LPS Hemoadsorption in Cardiac Surgery Patients · NA · recruiting
NCT06294119 — Multivariate Approach to the Numerical Assessment of Cortical - Autonomic - VAscular Dynamic Interplay · NA · recruiting
NCT07274436 — The Clinical Value of Deep Learning-Based Reconstruction Techniques in Cardiac MRI Scanning · recruiting
NCT07217392 — Left Bundle Branch Area Pacing (LBBAP) PMCF Study · NA · recruiting
NCT05877755 — Validation of Multi-contrast, High-resolution Cardiac Magnetic Resonance Imaging · NA · recruiting

Other Medtronic Cardiac Rhythm and Heart Failure trials

Trials by the same sponsor.

NCT06910059 — The CT-verified Data Collection Study to Investigate the Correlation Between the Leadless Pacemaker Tip Location and Ech · active not recruiting
NCT06745778 — Evolution of Intracardiac Electrograms Recorded by Left Bundle Branch Pacing Lead in Patients With ICD or CRT-D · recruiting
NCT06540521 — Bolt CSP-M Holter Study · recruiting
NCT06038123 — China 3T MRI Study · NA · completed
NCT06089694 — Crome/Cobalt Respiration Study · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05356546 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medtronic Cardiac Rhythm and Heart Failure
Last refreshed: 24 August 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05356546.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing