Adults 16 to 65, any sex, with Spinal Cord Injuries. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Reticulospinal Tract Excitability During Different Types of MovementsPrimary· During intervention, *1 Day*.
This primary outcome measures changes in reticulospinal tract excitability (RST) during training as quantified by changes in reaction time after a startling auditory stimulus.
RST contrubution was evaluated for dorsiflexion, plantarflexion, hip flexion movements during precision and range of motion control tasks under three conditions: with transcutaneous spinal cord stimulation or without stimulation. All conditions/evaluations were performed in the same session. 30 repetitions were performed per condition during a single session and averaged for each participant.
RST is a ratio calculated
RST: Hip flexion - range of motion - No stimulation
Group
Value
95% CI
Reaction Time Evaluation During Non-invasive Spinal Cord Stimulation and Leg Movements
1.405
± 0.285
RST: Hip flexion - precision control - No stimulation
Group
Value
95% CI
Reaction Time Evaluation During Non-invasive Spinal Cord Stimulation and Leg Movements
1.480
± 0.325
RST: Plantar flexion - range of motion - No stimulation
Group
Value
95% CI
Reaction Time Evaluation During Non-invasive Spinal Cord Stimulation and Leg Movements
1.443
± 0.325
RST: Plantar flexion - precision control - No stimulation
Group
Value
95% CI
Reaction Time Evaluation During Non-invasive Spinal Cord Stimulation and Leg Movements
1.455
± 0.258
RST: Dorsiflexion - range of motion - No stimulation
Group
Value
95% CI
Reaction Time Evaluation During Non-invasive Spinal Cord Stimulation and Leg Movements
1.544
± 0.578
RST: Dorsiflexion - precision control - No stimulation
Group
Value
95% CI
Reaction Time Evaluation During Non-invasive Spinal Cord Stimulation and Leg Movements
1.364
± 0.377
RST: Hip flexion - range of motion - stimulation
Group
Value
95% CI
Reaction Time Evaluation During Non-invasive Spinal Cord Stimulation and Leg Movements
1.497
± 0.569
RST: Hip flexion - precision control - stimulation
Group
Value
95% CI
Reaction Time Evaluation During Non-invasive Spinal Cord Stimulation and Leg Movements
1.689
± 0.667
Sponsor's own description
Spinal cord injury leads to long-lasting paralysis and impairment. Re-enabling movement of paralyzed areas is challenging and more information is needed about neurological recovery. The purpose of this study is to understand the contribution of individual neural tracts to movements facilitated by transcutaneous spinal cord stimulation (SCS).
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
Last refreshed: 22 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05354206.