NCT05342896: MINDdiet

Effect of Mediterranean-DASH Intervention for Neurodegenerative Delay Plus Forest Bathing

Completed NA Last updated 3 November 2023

What this trial tests

NA trial testing MIND diet in High Blood Pressure in 48 participants. Completed in 31 March 2023.

Timeline

3 January 2021

Primary endpoint
30 July 2022

31 March 2023

Quick facts

Lead sponsor	Hong Kong Metropolitan University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	health services research
Enrollment	48
Start date	3 January 2021
Primary completion	30 July 2022
Estimated completion	31 March 2023
Sites	1 location across Hong Kong

Drugs / interventions tested

• MIND diet
• Mind diet plus Forest Bathing

Conditions studied

• High Blood Pressure — all drugs for High Blood Pressure →

Sponsor

Hong Kong Metropolitan University

Who can join

60 and older, any sex, with High Blood Pressure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This proposed study will be the first to investigate the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Plus Forest Bathing (FB) on blood pressure (BP) and cognitive health for those who are aged 50 and above with hypertension. Hypertension is a major public health issue, and four developments make this research study remarkably important.

It is well-documented the Mediterranean diet and Dietary Approach to Stop Hypertension (DASH) diet have demonstrated efficacy for improving cardiovascular and cognitive health. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is a hybrid of the Mediterranean and DASH diets. FB promotes relaxation by inducing the activity of the parasympathetic nervous system, which decrease Heart rate and BP. The initial quantitative phase of the study, a three-arm RCT will be conducted to examine the effects of MIND, MIND plus FB and usual care as control on hypertension. The subsequent qualitative phase in-depth focus group interview is to explore the barriers and facilitators of MIND diet uptake and FB. The participants will include older HK Chinese adults who meet the criteria for hypertension stage 1 and stage 2 of the AHA. The primary outcomes are systolic BP and the secondary outcomes are point of care test of lipid panel, cognitive function, waist-to-hip ratio, body fat percentages and body mass index. The outcome measurements will be recorded before the interventions (T0), immediately after the 4-week face-to-face intervention (T1) and 12-week after 3-month intervention (T2). A total of 48 those who are aged 50 and above with hypertension will be recruited from community centres in Hong Kong to Randomized Controlled Trial and 10 participants differing in levels of compliance to MIND and FB will be purposively selected for face-to-face semi-structured focus group interviews.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effects of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and forest bathing in improving cognitive and metabolic health among hypertensive older adults: a feasibility randomised controlled trial.
   Law QPS, Yau KKY, Tyrovolas S, Kwan RYC. · · 2026 · PMID 41514353 · DOI 10.1186/s40795-026-01240-4