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NCT05342818
Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron
Phase 2 trial testing Neostigmine in Delayed Gastric Emptying in 90 participants. Completed in 17 October 2022.
30 July 2022
Quick facts
| Lead sponsor | Tanta University |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 90 |
| Start date | 15 April 2022 |
| Primary completion | 30 July 2022 |
| Estimated completion | 17 October 2022 |
| Sites | 1 location across Saudi Arabia |
Drugs / interventions tested
- Neostigmine (NEOSTIGMINE) — full drug profile →
- Ondansetron 8mg — full drug profile →
- Metoclopramide Injection
- Enteral feeding nutrition
- Sequential Organ Failure Assessment (SOFA) score
Conditions studied
- Delayed Gastric Emptying — all drugs for Delayed Gastric Emptying →
Sponsor
Tanta University
Who can join
Adults 25 to 75, any sex, with Delayed Gastric Emptying. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
One big problem in mechanically ventilated ICU patients is delayed gastric emptying. Delayed gastric emptying in these patients, causes intolerance and high gastric residual volume (GRV) that can lead to abdominal distention, vomiting, increased aspiration risk and consequently increased the length of hospital stay. In this study, investigators will evaluate Neostigmine's effect in reducing GRV in mechanically ventilated patients and compare its effect with metoclopramide and Ondansetron .
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05342818
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Neostigmine
Trials testing the same drug.
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- NCT07309393 — Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function · NA · recruiting
- NCT07203287 — Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease · Phase 4 · recruiting
- NCT06729047 — Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Pati · Phase 1, PHASE2 · not yet recruiting
- NCT06982092 — Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine. · Phase 1 · completed
Other recruiting trials for Delayed Gastric Emptying
Currently open trials in the same condition.
- NCT06452966 — The Impact and Effect of Traditional Chinese Medicine Treatment on Organ Failure in Critically Ill Patients · NA · recruiting
- NCT05674643 — Gastric Assessment of Pediatric Patients Undergoing Surgery · recruiting
Other Tanta University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05342818 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tanta University
- Last refreshed: 20 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05342818.
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