Last reviewed · How we verify
NCT05331651
Effect of Glycopyrronium in Combination With Tropisetron in Anti-postoperative Nausea and Vomiting
Phase 4 trial testing Glycopyrronium in Combination With Tropisetron in Postoperative Nausea and Vomiting in 480 participants. Completed in 30 June 2023.
30 June 2023
Quick facts
| Lead sponsor | The Second Affiliated Hospital of Chongqing Medical University |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 480 |
| Start date | 21 April 2022 |
| Primary completion | 30 June 2023 |
| Estimated completion | 30 June 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Glycopyrronium in Combination With Tropisetron — full drug profile →
- Normal Saline in Combination With Tropisetron — full drug profile →
Conditions studied
- Postoperative Nausea and Vomiting — all drugs for Postoperative Nausea and Vomiting →
Sponsor
The Second Affiliated Hospital of Chongqing Medical University
Who can join
Adults 18 to 70, any sex, with Postoperative Nausea and Vomiting. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To compare the anti-nausea and vomiting effect between glycopyrronium in combination with tropisetron and normal saline in combination with tropisetron for patients receiving elective surgery under general anesthesia. Based on this study the investigators intend to explore the feasibility of using glycopyrronium as adjuvant drug to prevent postoperative nausea and vomiting.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of Glycopyrronium Bromide as an Adjuvant Treatment in the Prevention of Nausea and Vomiting After Abdominal, Thyroid, and Breast Surgery: A Multicenter Randomized Controlled Trial.
Chen J, Piao G, Luan G, Yu Y, et al · · 2025 · PMID 40859968 · DOI 10.2147/dddt.s515670
Verify or expand the search:
- PubMed search for NCT05331651
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Postoperative Nausea and Vomiting
Currently open trials in the same condition.
- NCT07336160 — ERAS-Based Preoperative Nutrition and Fasting in Total Knee Arthroplasty · NA · recruiting
- NCT07242209 — Sugammadex and Menstrual Cycle in Postoperative Nausea and Vomiting · recruiting
- NCT07244575 — Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General · recruiting
- NCT06632184 — Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy · Phase 4 · active not recruiting
- NCT07271147 — Effects of taVNS Combined With Dexmedetomidine on POVN · NA · recruiting
Other The Second Affiliated Hospital of Chongqing Medical University trials
Trials by the same sponsor.
- NCT07534046 — Impact of Metabolic Disorders on cACLD Outcomes · not yet recruiting
- NCT07465003 — Cohort Study of Chronic Liver Disease Complicated by Sepsis · not yet recruiting
- NCT07339644 — Functional Lung Avoidance Radiotherapy Guided by 4DCT Pulmonary Ventilation Function Imaging: A Prospective Single-arm C · NA · recruiting
- NCT07048782 — Development and Validation of a Risk Prediction Model for Postoperative Visceral Pain in Abdominal Surgery Patients · not yet recruiting
- NCT07033949 — Effect of Green Light Exposure at Different Times on the Pain of Subjects · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05331651 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Second Affiliated Hospital of Chongqing Medical University
- Last refreshed: 16 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05331651.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing