Last reviewed · How we verify
NCT05284266
The National Lipedema Study
NA trial testing Liposuction early in Lipedema in 220 participants. Participants enrolled and being followed up; not accepting new ones.
31 October 2026
Quick facts
| Lead sponsor | Haraldsplass Deaconess Hospital |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 220 |
| Start date | 11 March 2022 |
| Primary completion | 31 October 2026 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across Norway |
Drugs / interventions tested
- Liposuction early
- Liposuction late
- Standard conservative treatment — full drug profile →
- Standard conservative treatment with Intermittent Pneumatic Compression (IPC)
Conditions studied
- Lipedema — all drugs for Lipedema →
Sponsor
Haraldsplass Deaconess Hospital
Who can join
Adults 20 to 65, female only, with Lipedema. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Lipedema is a chronic condition with a symmetrical accumulation of painful fatty tissue primarily affecting the limbs, sparing hands, feet and trunk. The subcutaneous fatty tissue is disproportionately voluminous and may have a different microstructure and metabolism than the patient's regular fatty tissue. The condition affects almost exclusively women and usually debuts around puberty. Lipedema seems to have a hereditary component, may be affected by hormonal variations and worsens with obesity. Guidelines advocate conservative treatment with compression therapy, weight management, physical activity, life style changes and psychological support;and in some cases surgical treatment such as bariatric surgery and liposuction. Treatment of lipedema is indicated when the condition causes significant pain and inhibits the patient's everyday activities. Well-designed randomized controlled studies on lipedema are lacking. The Ministry of Health and Care Services in Norway has found the scientific documentation for the effects of liposuction to be insufficient and has recommended that surgical treatment of lipedema should be evaluated through a 5-year clinical trial. A national task force, consisting of representatives from all four regional health authorities in Norway has been set up. This task force has now initiated this study. A national multi-center study with homogenous treatment protocols can provide globally sought insight on lipedema and the effect of its treatment regimes, and the findings will be important to adjust future treatment strategies regarding both effect and cost/effectiveness.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05284266
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Related trials
Other recruiting trials for Lipedema
Currently open trials in the same condition.
- NCT07489248 — Multimodal Ultrasound for Differentiating Lymphedema and Lipedema · recruiting
- NCT07468097 — The Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational · recruiting
- NCT07294014 — Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema · recruiting
- NCT07458932 — Evaluation of Physical Activity in Women With Lipedema · recruiting
- NCT06558851 — The Effect of Systematic Endurance Training in Treatment of Women With Lipedema · NA · active not recruiting
Other Haraldsplass Deaconess Hospital trials
Trials by the same sponsor.
- NCT05322993 — Improving Polyp Detection Rate by Artificial Intelligence in Colonoscopy · NA · completed
- NCT05119088 — Development of a Test Battery for Measurement of Knee Function in Patients With Patellar Instability · NA · completed
- NCT03776591 — Open D3 Right Hemicolectomy Compared to Laparoscopic CME for Right Sided Colon Cancer · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05284266 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Haraldsplass Deaconess Hospital
- Last refreshed: 22 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05284266.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing