NCT05278923

The Impact of Soiled Airway Management on CPR Quality

Completed NA Last updated 5 May 2022

What this trial tests

NA trial testing SALAD simulation device in Airway Aspiration in 54 participants. Completed in 11 March 2019.

Timeline

1 July 2018

Primary endpoint
11 March 2019

11 March 2019

Quick facts

Lead sponsor	Shin Kong Wu Ho-Su Memorial Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	health services research
Enrollment	54
Start date	1 July 2018
Primary completion	11 March 2019
Estimated completion	11 March 2019
Sites	1 location across Taiwan

Drugs / interventions tested

• SALAD simulation device

Conditions studied

• Airway Aspiration — all drugs for Airway Aspiration →
• Cardiopulmonary Arrest — all drugs for Cardiopulmonary Arrest →

Sponsor

Shin Kong Wu Ho-Su Memorial Hospital

Who can join

Eligibility, any sex, with Airway Aspiration or Cardiopulmonary Arrest. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Regurgitation is an adverse event common during cardiopulmonary resuscitation (CPR) and occurs in 20%-32% of patients experiencing out-of-hospital cardiac arrest (OHCA). It can impair ventilation, induce aspiration, and decrease survival to hospital discharge. Gastric fluid in the airway obscures the laryngeal view, thereby considerably decreasing the first-pass success of endotracheal intubation (ETI) by paramedics.

A human cadaver study reported that ETI outperforms other airway management devices, such as the i-gel, laryngeal mask, and laryngeal tube, in preventing aspiration when regurgitation occurs during CPR. However, ETI is also associated with multiple and prolonged CPR pauses.Compared with the use of supraglottic airway (SGA) devices, ETI results in more hands-off time during CPR. Recent randomised clinical trials have revealed that airway management with an SGA device provides superior outcomes to those of ETI in patients with OHCA. However, ETI remains the preferred management strategy for an airway affected by regurgitation in patients with OHCA.

Current guidelines focus on the quality of CPR because it is a key determinant of survival in patients with OHCA. However, evidence regarding the impact of regurgitation during ETI on CPR quality is limited. This manikin simulation study assessed CPR quality during ETI in airways with and without regurgitation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Compromised cardiopulmonary resuscitation quality due to regurgitation during endotracheal intubation: a randomised crossover manikin simulation study.
   Lin LW, DuCanto J, Hsu CY, Su YC, et al · · 2022 · cited 1× · PMID 35810275 · DOI 10.1186/s12873-022-00662-0