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NCT05276596: EPON
Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction
Phase 3 trial testing Ephedrine in Norepinephrine in 500 participants. Completed in 29 November 2025.
17 December 2024
Quick facts
| Lead sponsor | Centre Hospitalier Universitaire, Amiens |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 500 |
| Start date | 17 November 2021 |
| Primary completion | 17 December 2024 |
| Estimated completion | 29 November 2025 |
| Sites | 1 location across France |
Drugs / interventions tested
- Ephedrine (EPHEDRINE) — full drug profile →
- Norepinephrine (NOREPINEPHRINE) — full drug profile →
Conditions studied
- Norepinephrine — all drugs for Norepinephrine →
- Hypotension — all drugs for Hypotension →
- Anesthesiology — all drugs for Anesthesiology →
- Major Abdominal Surgery — all drugs for Major Abdominal Surgery →
Sponsor
Centre Hospitalier Universitaire, Amiens
Who can join
18 and older, any sex, with Norepinephrine or Hypotension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hemodynamic instability is frequent during surgery and intraoperative hypotension is associated with excess morbidity and excess mortality in high-risk patients. In major abdominal surgery the incidence of intraoperative hypotension remains high. For the past few years, some teams have proposed evaluating norepinephrine as a first-line drug in the presence of hypotension or even before hypotension occurs Thus in obstetrics, the preventive use of norepinephrine for cesareans performed under spinal anesthesia was associated with a reduction in the incidence of hypotension per operative without deleterious effect for the newborn or parturient. In the absence of any observed complications, several teams began to use noradrenaline prophylactically in other surgery. However, no study has demonstrated its benefit, particularly the term of surgical complication in abdominal surgery. The objective of this work is to assess the preventive use of norepinephrine in major abdominal surgery on the occurrence of intraoperative hypotension, postoperative organ dysfunction and postoperative medical and surgical complications.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Early Use of Norepinephrine in High-risk Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial.
Trocheris-Fumery O, Flet T, Scetbon C, Tarpin P, et al · · 2025 · cited 4× · PMID 40758953 · DOI 10.1097/aln.0000000000005704 -
Evaluation of the early use of norepinephrine in major abdominal surgery on medical and surgical postoperative complications: study protocol for a randomised controlled trial (EPON STUDY).
Trocheris-Fumery O, Scetbon C, Flet T, Meynier J, et al · · 2024 · cited 1× · PMID 38684243 · DOI 10.1136/bmjopen-2023-083606
Verify or expand the search:
- PubMed search for NCT05276596
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Related trials
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Trials testing the same drug.
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Other recruiting trials for Norepinephrine
Currently open trials in the same condition.
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Other Centre Hospitalier Universitaire, Amiens trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05276596 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire, Amiens
- Last refreshed: 3 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05276596.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing