NCT05274802 is a Phase 1 clinical trial of ALS-4 in Healthy Subject, sponsored by Aptorum International Limited.

Who is sponsoring NCT05274802?

NCT05274802 is sponsored by Aptorum International Limited.

What drugs are being tested in NCT05274802?

Interventions in NCT05274802: ALS-4, Placebo, ALS-4, ALS-4, Placebo.

What condition does NCT05274802 study?

NCT05274802 studies Healthy Subject.

Is NCT05274802 still recruiting?

NCT05274802 is currently completed. Last updated 25 April 2022.

Last reviewed 2022-04-25 · How we verify

NCT05274802

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Study of ALS-4 in Healthy Adults Subjects

Completed Phase 1 Last updated 25 April 2022

What this trial tests

Phase 1 trial testing ALS-4 in Healthy Subject in 72 participants. Completed in 2 January 2022.

Timeline

20 March 2021

Primary endpoint
22 December 2021

2 January 2022

Quick facts

Lead sponsor	Aptorum International Limited
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	triple
Primary purpose	treatment
Enrollment	72
Start date	20 March 2021
Primary completion	22 December 2021
Estimated completion	2 January 2022
Sites	1 location across Canada

Drugs / interventions tested

ALS-4 — full drug profile →
Placebo
ALS-4 — full drug profile →
ALS-4 — full drug profile →
Placebo

Conditions studied

Healthy Subject — all drugs for Healthy Subject →

Sponsor

Aptorum International Limited — full company profile →

Who can join

Adults 18 to 60, any sex, with Healthy Subject. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A Phase I trial to evaluate the safety, tolerability and Pharmacokinetics of ALS-4 (IM032) in a single ascending dose (SAD) and multiple ascending dose (MAD) in healthy adult subjects.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics.
Miller WR, Arias CA. · · 2024 · cited 481× · PMID 38831030 · DOI 10.1038/s41579-024-01054-w
Antibiotics in the clinical pipeline as of December 2022.
Butler MS, Henderson IR, Capon RJ, Blaskovich MAT. · · 2023 · cited 147× · PMID 37291465 · DOI 10.1038/s41429-023-00629-8
A Review of Antibacterial Candidates with New Modes of Action.
Butler MS, Vollmer W, Goodall ECA, Capon RJ, et al · · 2024 · cited 49× · PMID 39018341 · DOI 10.1021/acsinfecdis.4c00218
Antibacterials with Novel Chemical Scaffolds in Clinical Development.
Heimann D, Kohnhäuser D, Kohnhäuser AJ, Brönstrup M. · · 2025 · cited 10× · PMID 39847315 · DOI 10.1007/s40265-024-02137-x

Verify or expand the search:

Other recruiting trials for Healthy Subject

Currently open trials in the same condition.

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NCT03207854 — Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers · recruiting
NCT03199365 — Tu Salud Si Cuenta Intervention in Increasing Physical Activity and Healthy Eating Among Latino Families · NA · active not recruiting

Other Aptorum International Limited trials

Trials by the same sponsor.

NCT05358756 — A Study of Bioavailability and Food Effect of SACT-1 and Edurant® Tablets in Healthy Adult Volunteers · Phase 1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05274802 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Aptorum International Limited
Last refreshed: 25 April 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05274802.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing