Last reviewed · How we verify
NCT03897270
Photoacoustic Imaging of the Breast in Patients With Breast Cancer and Healthy Subjects
NA trial testing Photoacoustic Imaging in Breast Carcinoma in 400 participants. Currently enrolling.
25 August 2026
Quick facts
| Lead sponsor | Roswell Park Cancer Institute |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 400 |
| Start date | 25 October 2018 |
| Primary completion | 25 August 2026 |
| Estimated completion | 25 August 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Photoacoustic Imaging
Conditions studied
- Breast Carcinoma — all drugs for Breast Carcinoma →
- Healthy Subject — all drugs for Healthy Subject →
Sponsor
Roswell Park Cancer Institute
Who can join
18 and older, female only, with Breast Carcinoma or Healthy Subject. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This trial studies photoacoustic imaging of the breast in patients with breast cancer and healthy subjects. Dense breasts typically reduce the sensitivity of a mammography and also is associated with a higher risk of breast cancer. Photoacoustic tomography combines light and sound to provide more information about breast tissue.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Image-guided tumor surgery: The emerging role of nanotechnology.
Wojtynek NE, Mohs AM. · · 2020 · cited 34× · PMID 32162485 · DOI 10.1002/wnan.1624 -
Dual Function Antibody Conjugates for Multimodal Imaging and Photoimmunotherapy of Cancer Cells.
Saad MA, Xavierselvan M, Sharif HA, Selfridge S, et al · · 2022 · cited 14× · PMID 34379796 · DOI 10.1111/php.13501 -
Optimizing Axial and Peripheral Substitutions in Si-Centered Naphthalocyanine Dyes for Enhancing Aqueous Solubility and Photoacoustic Signal Intensity.
Saad MA, Pawle R, Selfridge S, Contreras L, et al · · 2023 · cited 6× · PMID 36768560 · DOI 10.3390/ijms24032241 -
Protocol to detect and quantify tumor hypoxia in mice using photoacoustic imaging.
Dai T, Rich LJ, Seshadri M, Dasgupta S. · · 2024 · cited 1× · PMID 38568814 · DOI 10.1016/j.xpro.2024.102993 -
Contrasting temporal dynamics of fluorescence and photoacoustic signals from Cetuximab-IRDye800 conjugate in EGFR-overexpressing tumors.
Saad MA, Allen D, Sweeney A, Xavierselvan M, et al · · 2026 · PMID 42090518 · DOI 10.1126/sciadv.adv4639 -
Clinical translation of photoacoustic imaging using exogenous molecular contrast agents [Invited].
Miao J, Luo M, Kotwal A, Hall E, et al · · 2025 · PMID 41293705 · DOI 10.1364/boe.577244
Verify or expand the search:
- PubMed search for NCT03897270
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Photoacoustic Imaging
Trials testing the same drug.
- NCT04185337 — Ultrasound-Guided Photoacoustic Imaging for the Detection of Metastases in Inguinal Lymph Nodes · EARLY_PHASE1 · completed
- NCT04110249 — Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer · NA · terminated
- NCT03630601 — Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft · NA · terminated
- NCT01755130 — Laser Optoacoustic and Ultrasonic Imaging System Assembly in Finding Changes in Tumors in Patients With Breast Cancer · NA · terminated
Other recruiting trials for Breast Carcinoma
Currently open trials in the same condition.
- NCT07067138 — A Synthetic Lethality-Focused Algorithm to Identify Therapeutic Options in Advanced Metastatic Breast Cancer (SYNTHESIS- · NA · recruiting
- NCT07291414 — A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients · NA · recruiting
- NCT07338721 — Does Ultrasound Guidance Axillary Incision Improve Sentinel Lymph Node Detection in Breast Cancer? · recruiting
- NCT07285044 — The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Tr · Phase 2 · recruiting
- NCT06731894 — Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors · Phase 2 · recruiting
Other Roswell Park Cancer Institute trials
Trials by the same sponsor.
- NCT07489287 — GB-5267 for the Treatment Platinum-Resistant Ovarian, Peritoneal, or Fallopian Tube Cancer · Phase 1 · not yet recruiting
- NCT06943664 — Photoimmunotherapy With ASP-1929 and Cemiplimab for the Treatment of Refractory, Inoperable, and Metastatic Stage IIIB-I · Phase 2 · not yet recruiting
- NCT06827054 — Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids · Phase 2 · not yet recruiting
- NCT06334016 — Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream · EARLY_PHASE1 · not yet recruiting
- NCT06670976 — Propranolol Plus Standard Radiation Therapy Before Surgery for the Treatment of Patients With Soft Tissue Sarcoma · Phase 1 · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03897270 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Roswell Park Cancer Institute
- Last refreshed: 7 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03897270.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing