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NCT05274113
Low Dose Dexamethasone for Distal Radius Fractures
Phase 3 trial testing Dexamethasone 4mg in Post Operative Pain in 50 participants. Status unknown.
31 March 2023
Quick facts
| Lead sponsor | Rothman Institute Orthopaedics |
|---|---|
| Phase | Phase 3 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 10 March 2022 |
| Primary completion | 31 March 2023 |
| Estimated completion | 31 March 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Dexamethasone 4mg — full drug profile →
- Ropivacaine (ROPIVACAINE) — full drug profile →
Conditions studied
- Post Operative Pain — all drugs for Post Operative Pain →
- Distal Radius Fracture — all drugs for Distal Radius Fracture →
Sponsor
Rothman Institute Orthopaedics
Who can join
18 and older, any sex, with Post Operative Pain or Distal Radius Fracture. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The addition of the steroid dexamethasone to a single injection of local anesthetic has been shown to significantly prolong the duration of peripheral nerve blockade compared to local anesthetic alone. This allows for improved post-operative pain scores and reduces opioid use in the early post-operative period. However, the use of a steroid adjuvant in regional nerve blocks is generally not considered standard of care, and there is considerable variation among anesthesiologists regarding preferred formulations and the role of adjuvants in regional anesthesia. A recent study from our institution demonstrated the effectiveness of dexamethasone directly mixed with local anesthetic at multiple doses compared to placebo for upper extremity surgery. With this prospective randomized controlled blinded trial, we hope to definitively establish which method of adjuvant dexamethasone administration is superior in extending the effects of a brachial plexus nerve block.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05274113
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Related trials
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Other recruiting trials for Post Operative Pain
Currently open trials in the same condition.
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- NCT07223580 — A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi · Phase 4 · recruiting
- NCT07227064 — Methadone in THA for Post-op Pain and Opioid Reduction · Phase 3 · recruiting
- NCT07226076 — Methadone in TKA for Post-op Pain and Opioid Reduction · Phase 3 · recruiting
- NCT07349810 — Post Operative Infusion Pump Pain Study · Phase 4 · recruiting
Other Rothman Institute Orthopaedics trials
Trials by the same sponsor.
- NCT06903767 — Automated V Manual Impactor Study · NA · enrolling by invitation
- NCT06601803 — Surgiphor Us in TSA · Phase 4 · enrolling by invitation
- NCT06575010 — Exparel v Dexamethasone in RCR · Phase 4 · enrolling by invitation
- NCT06536842 — Wound Drain After Lumbar Fusion Surgery · NA · enrolling by invitation
- NCT06484192 — Pain Control After Lumbar Spine Fusion · Phase 4 · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05274113 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rothman Institute Orthopaedics
- Last refreshed: 10 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05274113.
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