NCT05271786 is a clinical trial of Decannulation in Tracheostomy Weaning, sponsored by University of Milan.

Who is sponsoring NCT05271786?

NCT05271786 is sponsored by University of Milan.

What drugs are being tested in NCT05271786?

Interventions in NCT05271786: Decannulation.

What condition does NCT05271786 study?

NCT05271786 studies Tracheostomy Weaning, Tracheostomy Decannulation.

Is NCT05271786 still recruiting?

NCT05271786 is currently completed. Last updated 10 September 2025.

Last reviewed 2025-09-10 · How we verify

NCT05271786

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

WEANING FROM TRACHEOSTOMY

Completed Last updated 10 September 2025

What this trial tests

trial testing Decannulation in Tracheostomy Weaning in 192 participants. Completed in 30 November 2023.

Timeline

1 April 2022

Primary endpoint
30 November 2023

30 November 2023

Quick facts

Lead sponsor	University of Milan
Status	Completed
Study type	OBSERVATIONAL
Enrollment	192
Start date	1 April 2022
Primary completion	30 November 2023
Estimated completion	30 November 2023
Sites	1 location across Italy

Drugs / interventions tested

Decannulation

Conditions studied

Tracheostomy Weaning — all drugs for Tracheostomy Weaning →
Tracheostomy Decannulation — all drugs for Tracheostomy Decannulation →

Sponsor

University of Milan

Who can join

18 and older, any sex, with Tracheostomy Weaning or Tracheostomy Decannulation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Tracheostomy is a very common surgical procedure performed in critically ill patients on invasive mechanical ventilation, and usually performed in difficult-to-wean patients and whn prolonged mechanical ventilation is required. Weaning from the tracheostomy cannula (i.e. decannulation) represents one of the crucial steps in the post-acute respiratory management of these patients. Tracheostomy literature mainly focuses on the timing and technique of this procedure, but there is a lack of studies about decannulation and, currently, our knowledge is primarily based on expert opinion. The COVID-19 pandemic, due to the rapid increase in the number of patients exposed to prolonged mechanical ventilation, has stressed the need for objective parameters and shared standardized protocols to perform weaning from tracheostomy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Determinants of time to decannulation and predictors of early weaning from tracheostomy: a multicenter, retrospective Italian cohort study.
Radovanovic D, Di Marco F, Mondoni M, Crimi C, et al · · 2026 · PMID 41884465 · DOI 10.1016/j.aicoj.2026.100050

Verify or expand the search:

Other trials of Decannulation

Trials testing the same drug.

NCT06167538 — Clinical Outcome Following Early Decannulation of Severe Acquired Brain Injury Patients · unknown

Other recruiting trials for Tracheostomy Weaning

Currently open trials in the same condition.

NCT06776939 — Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning f · NA · recruiting

Other University of Milan trials

Trials by the same sponsor.

NCT07476417 — Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study. · not yet recruiting
NCT07259902 — FMRI Study on DC/TMD Patients · NA · not yet recruiting
NCT07273123 — The Effect of Prolonged Sugar-Free Chewing Gum Mastication on Self-Reported Fatigue Levels and Changes of Static and Dyn · recruiting
NCT07262437 — Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles · NA · active not recruiting
NCT07312305 — Small Airways Disease Functional Assessment in Idiopathic Pulmonary Fibrosis (SWIFT-IPF) · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05271786 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Milan
Last refreshed: 10 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05271786.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing