Last reviewed · How we verify
NCT05270707
HyperArc Registry Study
trial testing Stereotactic radiosurgery in Brain Metastases in 968 participants. Completed in 31 March 2025.
31 March 2025
Quick facts
| Lead sponsor | Varian, a Siemens Healthineers Company |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 968 |
| Start date | 31 March 2022 |
| Primary completion | 31 March 2025 |
| Estimated completion | 31 March 2025 |
| Sites | 7 locations across Belgium, Italy, United States, Australia |
Drugs / interventions tested
- Stereotactic radiosurgery
Conditions studied
- Brain Metastases — all drugs for Brain Metastases →
- CNS Neoplasm — all drugs for CNS Neoplasm →
- CNS Disorder, Intracranial — all drugs for CNS Disorder, Intracranial →
Sponsor
Varian, a Siemens Healthineers Company — full company profile →
Who can join
18 and older, any sex, with Brain Metastases or CNS Neoplasm. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The HyperArc registry is designed to collect data from which the efficacy of the HyperArc procedure can be assessed and compared to alternative treatments.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05270707
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Stereotactic radiosurgery
Trials testing the same drug.
- NCT06466720 — Measuring and Mapping Cognitive Decline After Brain Radiosurgery · recruiting
- NCT05641441 — Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma · recruiting
- NCT05177185 — Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife · Phase 2 · unknown
- NCT04785521 — Glutamate Excitotoxicity in Brain Metastases From Lung, Breast and Melanoma Treated With Stereotactic Radiosurgery · active not recruiting
- NCT02886572 — SIMT Stereotactic Radiosurgery Outcomes Study · NA · completed
Other recruiting trials for Brain Metastases
Currently open trials in the same condition.
- NCT07464470 — Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers · recruiting
- NCT07481786 — Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases · Phase 3 · recruiting
- NCT07227610 — Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT) · Phase 2 · recruiting
- NCT07448493 — Local Treatment Strategies for Brain Metastases of Gastric and Esophageal Cancer · active not recruiting
- NCT07053033 — Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR Be · Phase 2 · recruiting
Other Varian, a Siemens Healthineers Company trials
Trials by the same sponsor.
- NCT06347731 — Varian ProBeam360° Proton Therapy System China Clinical Trial (Wuhan) · NA · completed
- NCT05666193 — On-treatment Adaptation of Head and Neck Cancer Dosimetry Plans Using Novel Cone-beam CT and AI-driven Software · NA · completed
- NCT05524454 — Evaluation of a Cone-beam CT Scanner for Image Guided Radiotherapy · NA · completed
- NCT05524064 — FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases in the Thorax · NA · active not recruiting
- NCT05700227 — Daily Online Adaptive Short-Course Radiation Therapy and Concurrent Chemotherapy for Muscle-Invasive Bladder Cancer · NA · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05270707 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Varian, a Siemens Healthineers Company
- Last refreshed: 24 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05270707.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing