NCT05666193 is a NA clinical trial of CBCT Imaging in Head and Neck Cancer, sponsored by Varian, a Siemens Healthineers Company.

Who is sponsoring NCT05666193?

NCT05666193 is sponsored by Varian, a Siemens Healthineers Company.

What drugs are being tested in NCT05666193?

Interventions in NCT05666193: CBCT Imaging.

What condition does NCT05666193 study?

NCT05666193 studies Head and Neck Cancer.

Is NCT05666193 still recruiting?

NCT05666193 is currently completed. Last updated 4 February 2025.

Last reviewed 2025-02-04 · How we verify

NCT05666193

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

On-treatment Adaptation of Head and Neck Cancer Dosimetry Plans Using Novel Cone-beam CT and AI-driven Software

Completed NA Last updated 4 February 2025

What this trial tests

NA trial testing CBCT Imaging in Head and Neck Cancer in 30 participants. Completed in 19 December 2024.

Timeline

10 July 2023

Primary endpoint
19 December 2024

19 December 2024

Quick facts

Lead sponsor	Varian, a Siemens Healthineers Company
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	30
Start date	10 July 2023
Primary completion	19 December 2024
Estimated completion	19 December 2024
Sites	1 location across Canada

Drugs / interventions tested

CBCT Imaging

Conditions studied

Head and Neck Cancer — all drugs for Head and Neck Cancer →

Sponsor

Varian, a Siemens Healthineers Company — full company profile →

Who can join

19 and older, any sex, with Head and Neck Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a feasibility study investigating the use of a high-performance HyperSight cone beam CT (CBCT) and adaptive planning software for both online and offline radiotherapy treatment planning for head and neck cancer.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

HyperSight CBCT image quality and metal artifact reduction for adaptive head and neck radiotherapy: Results from a prospective clinical trial.
Yashayaeva A, MacDonald RL, Zhan K, DeGiobbi J, et al · · 2025 · cited 1× · PMID 41316883 · DOI 10.1002/acm2.70338

Verify or expand the search:

Other trials of CBCT Imaging

Trials testing the same drug.

NCT05176860 — Evaluation of Novel Cone-Beam CT for Guidance and Adaptation of Precision Radiotherapy · NA · completed

Other recruiting trials for Head and Neck Cancer

Currently open trials in the same condition.

NCT07318220 — Prehabilitation Protocol for Head and Neck Cancer Patients · NA · recruiting
NCT07524114 — Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception · recruiting
NCT07467083 — Development and Application of a Nurse-Led Preemptive Symptom Management Protocol for Head and Neck Cancer Patients Unde · Phase 3 · recruiting
NCT07209189 — Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-esca · Phase 2 · recruiting
NCT06837480 — Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema · NA · recruiting

Other Varian, a Siemens Healthineers Company trials

Trials by the same sponsor.

NCT06347731 — Varian ProBeam360° Proton Therapy System China Clinical Trial (Wuhan) · NA · completed
NCT05524454 — Evaluation of a Cone-beam CT Scanner for Image Guided Radiotherapy · NA · completed
NCT05524064 — FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases in the Thorax · NA · active not recruiting
NCT05700227 — Daily Online Adaptive Short-Course Radiation Therapy and Concurrent Chemotherapy for Muscle-Invasive Bladder Cancer · NA · terminated
NCT06338436 — Varian ProBeam Proton Therapy System China Clinical Trial (Guangzhou) · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05666193 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Varian, a Siemens Healthineers Company
Last refreshed: 4 February 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05666193.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing