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NCT05266976: MOVE
Mode of Exercise and Bone Biomarkers in Older Veterans
NA trial testing 10 Weeks of Supervised Resistance Exercise Training in Aging in 120 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 120 |
| Start date | 6 July 2022 |
| Primary completion | 1 December 2026 |
| Estimated completion | 31 March 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- 10 Weeks of Supervised Resistance Exercise Training
- 10 Weeks of Supervised Endurance Exercise Training
Conditions studied
- Aging — all drugs for Aging →
- Musculoskeletal Diseases — all drugs for Musculoskeletal Diseases →
- Osteoporosis — all drugs for Osteoporosis →
Sponsor
VA Office of Research and Development — full company profile →
Who can join
60 and older, any sex, with Aging or Musculoskeletal Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders.
Cento AS, Leigheb M, Caretti G, Penna F. · · 2022 · cited 28× · PMID 35881303 · DOI 10.1007/s11914-022-00739-6
Verify or expand the search:
- PubMed search for NCT05266976
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other VA Office of Research and Development trials
Trials by the same sponsor.
- NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
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- NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
- NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
- NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05266976 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
- Last refreshed: 5 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05266976.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing