NCT05264636 is a NA clinical trial of Sucrose in Healthy, sponsored by Cargill.

Who is sponsoring NCT05264636?

NCT05264636 is sponsored by Cargill.

What drugs are being tested in NCT05264636?

Interventions in NCT05264636: Sucrose, Steviol Glycosides.

What condition does NCT05264636 study?

NCT05264636 studies Healthy, Human Gut Microflora.

Is NCT05264636 still recruiting?

NCT05264636 is currently completed. Last updated 28 April 2023.

Last reviewed 2023-04-28 · How we verify

NCT05264636

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Impact of Steviol Glycosides on Human Gut Microflora Profile and Function

Completed NA Last updated 28 April 2023

What this trial tests

NA trial testing Sucrose in Healthy in 59 participants. Completed in 29 August 2022.

Timeline

15 February 2022

Primary endpoint
29 August 2022

29 August 2022

Quick facts

Lead sponsor	Cargill
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	basic science
Enrollment	59
Start date	15 February 2022
Primary completion	29 August 2022
Estimated completion	29 August 2022
Sites	1 location across Canada

Drugs / interventions tested

Sucrose — full drug profile →
Steviol Glycosides

Conditions studied

Healthy — all drugs for Healthy →
Human Gut Microflora — all drugs for Human Gut Microflora →

Sponsor

Cargill — full company profile →

Who can join

Adults 18 to 50, any sex, with Healthy or Human Gut Microflora. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Diet and dietary ingredients can have a profound effect on gut microflora, both positive and negative. The reported effects on low and non caloric sweeteners (LNCS) on human gut microflora are contradictory in some of the in vitro and rodent studies. More specifically, the latter studies, using doses above the acceptable daily intake (ADI), suggest that LNCS may have adverse effects on gut microflora whereas recent data from human RCTs, using doses at or below the ADI, show little to no effect. In this study we will compare the effects of a low energy beverage made with steviol glycosides vs. a beverage made with sucrose on human gut microflora profile and function in a double blind, randomized study. A sucrose beverage was chosen as a control as it represents a caloric sugar sweetened beverage which is commonly consumed.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Comparison of a Daily Steviol Glycoside Beverage compared with a Sucrose Beverage for Four Weeks on Gut Microbiome in Healthy Adults.
Kwok D, Scott C, Strom N, Au-Yeung F, et al · · 2024 · cited 10× · PMID 38408729 · DOI 10.1016/j.tjnut.2024.01.032
Health Effects of Sugar-Sweetened and Artificially Sweetened Beverages: Umbrella Review and Evidence-Based Consensus Statement of the Korean Diabetes Association and the Korean Nutrition Society.
Choi JH, Song S, Kim SK, Cho JW, et al · · 2026 · cited 2× · PMID 41531289 · DOI 10.4093/dmj.2025.0848

Verify or expand the search:

Other trials of Sucrose

Trials testing the same drug.

NCT06724705 — Testing the Capability of the Smart Underwear Device to Detect Increased Microbiome Activity Following Lactose Consumpti · NA · recruiting
NCT06477770 — Sucrose as a Standard in Cesarean Section Surgical Wound Healing to Reduce Hospital Time · NA · active not recruiting
NCT06107231 — WHNRC (Western Human Nutrition Research Center) Honey Study · NA · active not recruiting
NCT05705596 — Impact of Hesperetin in Combination With Sucrose on Energy Metabolism · EARLY_PHASE1 · completed
NCT05671965 — Effects of Oral Xylitol on Subsequent Energy Intake · NA · completed

Other recruiting trials for Healthy

Currently open trials in the same condition.

NCT06707207 — Predicting Future Errors During Skill Performance · recruiting
NCT07169630 — PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) · Phase 1 · recruiting
NCT07499414 — The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease. · NA · recruiting
NCT07496697 — Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects · NA · recruiting
NCT06431932 — Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity · Phase 1, PHASE2 · recruiting

Other Cargill trials

Trials by the same sponsor.

NCT05819424 — EpiCor Clinical Study on Rapid Immune Modulating Effects · NA · completed
NCT05492370 — Effects of a Yeast Fermentate (EpiCor) Supplement on Cold or Flu Symptoms in Healthy Children · NA · completed
NCT04093206 — Compare Effects of EpiCor and Vitamin C to Vitamin C Alone on the Common Cold or Influenza in Healthy Children · NA · completed
NCT03239288 — A Randomized, Controlled, Crossover Study to Assess the Glucose and Insulin Excursions of a Test Fiber · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05264636 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Cargill
Last refreshed: 28 April 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05264636.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing