NCT05255913 is a NA clinical trial of Nanosilver in Early Childhood Caries, sponsored by Alexandria University.

Who is sponsoring NCT05255913?

NCT05255913 is sponsored by Alexandria University.

What drugs are being tested in NCT05255913?

Interventions in NCT05255913: Nanosilver, Silver diamine fluoride.

What condition does NCT05255913 study?

NCT05255913 studies Early Childhood Caries.

Is NCT05255913 still recruiting?

NCT05255913 is currently completed. Last updated 26 September 2023.

Last reviewed 2023-09-26 · How we verify

NCT05255913

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effectiveness of Nano-silver Fluoride and Silver Diamine Fluoride for Arresting Early Childhood Caries

Completed NA Last updated 26 September 2023

What this trial tests

NA trial testing Nanosilver in Early Childhood Caries in 360 participants. Completed in 3 August 2023.

Timeline

15 March 2022

Primary endpoint
25 July 2023

3 August 2023

Quick facts

Lead sponsor	Alexandria University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	360
Start date	15 March 2022
Primary completion	25 July 2023
Estimated completion	3 August 2023
Sites	1 location across Egypt

Drugs / interventions tested

Nanosilver — full drug profile →
Silver diamine fluoride — full drug profile →

Conditions studied

Early Childhood Caries — all drugs for Early Childhood Caries →

Sponsor

Alexandria University

Who can join

Adults 2 to 4, any sex, with Early Childhood Caries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Aim of the study: To evaluate and compare the clinical cariostatic efficacy of NSF with 38% SDF solution after sex and twelve months in arresting ECC lesions. The Null hypothesis will be that no statistically significant difference will be detected between the two groups in the arrest of carious lesions in children with ECC.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Effectiveness of nanosilver fluoride and silver diamine fluoride in arresting early childhood caries: a randomized controlled clinical trial.
Quritum M, Abdella A, Amer H, El Desouky LM, et al · · 2024 · cited 15× · PMID 38890627 · DOI 10.1186/s12903-024-04406-3
Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults.
Worthington HV, Lewis SR, Glenny AM, Huang SS, et al · · 2024 · cited 8× · PMID 39508296 · DOI 10.1002/14651858.cd012718.pub2
Effect of silver diamine fluoride and nano silver fluoride on oral health-related quality of life of children with early childhood caries: A randomized clinical trial.
Quritum M, Abdella A, Amer H, El Tantawi M. · · 2024 · cited 5× · PMID 38311016 · DOI 10.1016/j.jdent.2024.104878

Verify or expand the search:

Other recruiting trials for Early Childhood Caries

Currently open trials in the same condition.

NCT05761197 — Oropharyngeal Candidiasis (OPC) and S-ECC · recruiting
NCT06441500 — Oral Health and Dental Caries Prevention Intervention for Children in Romania · NA · recruiting
NCT06241261 — Arresting Early Childhood Caries With a Silver Diamine Fluoride Gel · Phase 2 · active not recruiting
NCT05716867 — Salivary Cystatin S Levels in a Group of Egyptian Children · active not recruiting

Other Alexandria University trials

Trials by the same sponsor.

NCT07517861 — Integrated Mental Health Nursing Program: Effects on Stigma, Cognitive Flexibility, and Clinical Readiness · NA · recruiting
NCT07476482 — The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delive · NA · enrolling by invitation
NCT07476209 — Sialendoscopy Versus Photobiomodulation in Prevention of Radiation Induced Xerostomia · NA · recruiting
NCT07503626 — Optimization of Orthodontic Bracket Placement by Using Two Different Protocols of Digitally Aided Bonding · NA · recruiting
NCT07522944 — AI-Guided Relaxation for Hemodialysis Anxiety · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05255913 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Alexandria University
Last refreshed: 26 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05255913.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing