Last reviewed 2026-05-28 · How we verify

Silver diamine fluoride

Silver diamine fluoride is a Topical antimicrobial and remineralizing agent Small molecule drug developed by Postgraduate Institute of Dental Sciences Rohtak. It is currently FDA-approved for Dental caries arrest and prevention in primary and permanent teeth, Early childhood caries management, Root caries in elderly patients. Also known as: FAgamin SDF38%, SDF, Advantage Arrest, SDF gel.

Silver diamine fluoride arrests dental caries by releasing silver ions that kill cariogenic bacteria and fluoride ions that remineralize tooth structure.

Silver diamine fluoride is a topical medication used to treat and prevent dental caries and relieve dentinal hypersensitivity. It has been studied for its effectiveness in treating conditions such as gingivitis, periodontitis, and periodontal disease, with one clinical trial specifically examining its use in geriatric patients with gingivitis.

At a glance

Mechanism of action

Silver diamine fluoride is a topical antimicrobial and remineralizing agent used in dentistry. The silver component provides bactericidal activity against oral pathogens, particularly Streptococcus mutans, while the fluoride component promotes remineralization of early carious lesions and strengthens tooth enamel. The combination arrests caries progression without requiring tooth removal.

Approved indications

• Dental caries arrest and prevention in primary and permanent teeth
• Early childhood caries management
• Root caries in elderly patients

Common side effects

• Tooth staining (black/dark discoloration)
• Gum irritation or staining
• Metallic taste

Key clinical trials

• Preventing Early Childhood Caries With a Silver Diamine Fluoride Gel (PHASE2)
• Arresting Early Childhood Caries With a Silver Diamine Fluoride Gel (PHASE2)
• Traditional vs. Minimally Invasive Decay Treatments in Primary Molars: An 18-month Split-mouth Randomized Study (NA)
• Building Adaptive School-based Interventions for Caries (PHASE3)
• Silver Diamine Fluoride in Molar-Incisor Hypomineralisation (NA)
• Effects of Different Remineralization Agents on the Progression of Non-Cavitated Approximal Carious Lesions in Primary Teeth: A Randomized Clinical Trial (NA)
• General Dentists' Knowledge, Attitudes and Clinical Usage of SDF
• Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars (NA)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Silver diamine fluoride CI brief — competitive landscape report
• Silver diamine fluoride updates RSS · CI watch RSS
• Postgraduate Institute of Dental Sciences Rohtak portfolio CI

Frequently asked questions about Silver diamine fluoride

Related

• Drug class: All Topical antimicrobial and remineralizing agent drugs
• Manufacturer: Postgraduate Institute of Dental Sciences Rohtak — full pipeline
• Therapeutic area: All drugs in Dentistry / Dental Caries Prevention
• Indication: Drugs for Dental caries arrest and prevention in primary and permanent teeth
• Indication: Drugs for Early childhood caries management
• Indication: Drugs for Root caries in elderly patients
• Also known as: FAgamin SDF38%, SDF, Advantage Arrest, SDF gel, SDF solution

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing