NCT05253508

Propagation Waves in Tactile Material Perception

Status unknown NA Last updated 23 February 2022

What this trial tests

NA trial testing Lidocaine 2% Injectable Solution in Sensory Processing in 15 participants. Status unknown.

Timeline

1 January 2022

Primary endpoint
15 March 2022

30 March 2022

Quick facts

Lead sponsor	Reinier Haga Orthopedisch Centrum
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	sequential
Masking	none
Primary purpose	basic science
Enrollment	15
Start date	1 January 2022
Primary completion	15 March 2022
Estimated completion	30 March 2022
Sites	1 location across Netherlands

Drugs / interventions tested

• Lidocaine 2% Injectable Solution — full drug profile →

Conditions studied

• Sensory Processing — all drugs for Sensory Processing →
• Perception — all drugs for Perception →
• Sense of Touch — all drugs for Sense of Touch →
• Taction — all drugs for Taction →

Sponsor

Reinier Haga Orthopedisch Centrum

Who can join

18 and older, any sex, with Sensory Processing or Perception. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

During the exploration of surfaces with the bare finger, vibratory signals arise and propagate through the finger and hand. While research into mechanical and neural response characteristics has demonstrated that these signals carry rich information about touched objects and their properties, only little is known about the role these propagation waves play in human perception and to which extent the somatosensory system is able to collect information from afferents at more proximal locations than the skin-object surface. Using ring-block anaesthesia (lidocaine) we will temporarily inhibit haptic feedback sensations of healthy participants' index finger during interactions with 3D-printed surface probes that are systematically varied in two important material dimensions, namely their roughness and hardness (elasticity), while the participants carry out a well-established psychophysical discrimination task. The results will then be compared to a control condition without anaesthesia. An accelerometer sensor, placed on the dorsal side of the hand, will serve to simultaneously record the propagating tactile waves. Given their role in material perception, thermal cues will be monitored during the experiment with a thermometer and the hydration level of the fingertip skin will be measured regularly using a corneometer. This research will allow us to understand the role of propagation waves in material perception. It seeks to uncover some of the perceptual mechanisms that remain intact during surface discrimination of textured, compliant surfaces, while local information is temporarily inhibited. The results will have implications for how we provide feedback about material properties for sensorimotor control to this living with prosthetic limbs. It is hypothesised that propagation waves that arise during these haptic interactions contain behaviourally relevant information used for the discrimination of surface properties.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Increased temporal binding during voluntary motor task under local anesthesia.
   Driller KK, Fradet C, Mathijssen N, Kraan G, et al · · 2023 · PMID 37666870 · DOI 10.1038/s41598-023-40591-x