Last reviewed · How we verify
NCT05250375
Natural History Study of Mitochondrial Myopathy
trial in Primary Mitochondrial Disease in 1,300 participants. Currently enrolling.
24 March 2030
Quick facts
| Lead sponsor | Children's Hospital of Philadelphia |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,300 |
| Start date | 24 March 2017 |
| Primary completion | 24 March 2030 |
| Estimated completion | 24 March 2030 |
| Sites | 1 location across United States |
Conditions studied
- Primary Mitochondrial Disease — all drugs for Primary Mitochondrial Disease →
Sponsor
Children's Hospital of Philadelphia
Who can join
Adults 0 to 100, any sex, with Primary Mitochondrial Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to develop and validate tools to measure disease course in patients with primary mitochondrial myopathy (PMM). The main aims of this study are: * Development, validation, and optimization of objective outcome measures for mitochondrial myopathy * Defining the natural history of mitochondrial myopathy Researchers will compare data from patients with primary mitochondrial myopathy to healthy controls. Data from healthy controls will also help define normative data for future studies. Participants will perform clinical exams of muscle strength and endurance and will complete surveys.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05250375
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Primary Mitochondrial Disease
Currently open trials in the same condition.
- NCT06890520 — Neurometabolic Profile of Individuals With Primary Mitochondrial Disease · recruiting
Other Children's Hospital of Philadelphia trials
Trials by the same sponsor.
- NCT07023380 — EoE Food Test Pilot Study · NA · not yet recruiting
- NCT06693752 — CEUS Evaluation of Hydrocephalus in Neonates and Infants · Phase 2 · recruiting
- NCT07425691 — SPACE for Youth With Chronic Pain · recruiting
- NCT07444528 — Upper Airway Ultrasound to Predict Difficult Laryngoscopy in Neonates and Infants · enrolling by invitation
- NCT07321327 — Implementation Strategies for Caregiver and Teacher Use of Behavioral Interventions: Aim 2 · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05250375 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Hospital of Philadelphia
- Last refreshed: 10 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05250375.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing