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NCT05249309
Naturalistic Study of Ketamine in the Treatment of Depression
trial testing Ketamine in Major Depressive Disorder in 90 participants. Status unknown.
1 November 2022
Quick facts
| Lead sponsor | Hospital de Clinicas de Porto Alegre |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 90 |
| Start date | 1 May 2021 |
| Primary completion | 1 November 2022 |
| Estimated completion | 15 December 2023 |
| Sites | 2 locations across Brazil |
Drugs / interventions tested
- Ketamine (ketamine) — full drug profile →
Conditions studied
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
- Bipolar Disorder — all drugs for Bipolar Disorder →
- Bipolar Depression — all drugs for Bipolar Depression →
- Bipolar I Disorder — all drugs for Bipolar I Disorder →
Sponsor
Hospital de Clinicas de Porto Alegre
Who can join
18 and older, any sex, with Major Depressive Disorder or Bipolar Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to examine the effect of ketamine in decreasing the risk of suicide in patients with depression and its effectiveness as an antidepressant agent.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Ketamine for bipolar depression: an updated systematic review.
Fancy F, Haikazian S, Johnson DE, Chen-Li DCJ, et al · · 2023 · cited 15× · PMID 37771417 · DOI 10.1177/20451253231202723 -
Ketamine study: Protocol for naturalistic prospective multicenter study on subcutaneous ketamine infusion in depressed patients with active suicidal ideation.
Anzolin AP, Goularte JF, Pinto JV, Belmonte-de-Abreu P, et al · · 2023 · cited 3× · PMID 36970275 · DOI 10.3389/fpsyt.2023.1147298 -
SIRT3/6/7: promising therapeutic targets for pulmonary fibrosis.
Huang P, Qin D, Qin Y, Tao S, et al · · 2025 · cited 2× · PMID 40241794 · DOI 10.3389/fcell.2025.1557384 -
Subcutaneous ketamine reduces suicide risk and improves functioning in depression: A proof-of-concept study.
Anzolin AP, Baldez DP, Montezano BB, Kapczinski F, et al · · 2024 · PMID 38688118 · DOI 10.1016/j.psychres.2024.115915
Verify or expand the search:
- PubMed search for NCT05249309
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Major Depressive Disorder
Currently open trials in the same condition.
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- NCT06749392 — An Individual-specific Synchrony Signature · NA · recruiting
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- NCT07242105 — Optimizing Brain Excitability in Depression · NA · recruiting
Other Hospital de Clinicas de Porto Alegre trials
Trials by the same sponsor.
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- NCT07264179 — Tracheal Cuff Pressure and Postoperative Complications: A Prospective Observational Study. · not yet recruiting
- NCT07052058 — Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to · Phase 2 · not yet recruiting
- NCT06953128 — General Versus Regional Anesthesia in Peripheral Arterial Surgery · NA · not yet recruiting
- NCT06934707 — Meal Frequency and Glycemic Control in Individuals With Type 1 Diabetes · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05249309 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital de Clinicas de Porto Alegre
- Last refreshed: 25 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05249309.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing