Last reviewed · How we verify
NCT05246813
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
trial testing Blood and bone marrow cell collection in Osteoporosis in 24 participants. Currently enrolling.
31 December 2028
Quick facts
| Lead sponsor | Imelda Hospital, Bonheiden |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 24 |
| Start date | 11 February 2022 |
| Primary completion | 31 December 2028 |
| Estimated completion | 31 December 2030 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Blood and bone marrow cell collection
Conditions studied
- Osteoporosis — all drugs for Osteoporosis →
- Osteoarthritis, Hip — all drugs for Osteoarthritis, Hip →
- Hip Fractures — all drugs for Hip Fractures →
- Clonal Hematopoiesis of Indeterminate Potential — all drugs for Clonal Hematopoiesis of Indeterminate Potential →
Sponsor
Imelda Hospital, Bonheiden
Who can join
55 and older, any sex, with Osteoporosis or Osteoarthritis, Hip. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Clonal hematopoiesis and cardiovascular disease: deciphering interconnections.
Stein A, Metzeler K, Kubasch AS, Rommel KP, et al · · 2022 · cited 25× · PMID 36355225 · DOI 10.1007/s00395-022-00969-w
Verify or expand the search:
- PubMed search for NCT05246813
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Osteoporosis
Currently open trials in the same condition.
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- NCT07367776 — Patient Education in Osteoporosis (RCT-PATOS) · NA · recruiting
- NCT06731608 — OsteoPorotic fracTure preventION System (OPTIONS) Research Study · NA · recruiting
- NCT07281586 — Step-down Therapy After Long-term Osteoporosis Treatment · Phase 4 · recruiting
- NCT07083557 — Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiome · recruiting
Other Imelda Hospital, Bonheiden trials
Trials by the same sponsor.
- NCT04755101 — Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated Syncope · NA · recruiting
- NCT04770597 — Monitors to Improve Indoor Carbon Dioxide (CO2) Concentrations in the Hospital · NA · completed
- NCT02954666 — Second Study on Cardio-neuromodulation in Humans · NA · completed
- NCT02630329 — Notes Adnexectomy for Benign Pathology Compared to Laparoscopic Excision · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05246813 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Imelda Hospital, Bonheiden
- Last refreshed: 25 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05246813.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing