NCT02954666 (CardNMH2) is a NA clinical trial of radio-frequency ablation in Cardiac Disease, sponsored by Imelda Hospital, Bonheiden.

Who is sponsoring NCT02954666?

NCT02954666 is sponsored by Imelda Hospital, Bonheiden.

What drugs are being tested in NCT02954666?

Interventions in NCT02954666: radio-frequency ablation.

What condition does NCT02954666 study?

NCT02954666 studies Cardiac Disease, Syncope, Syncope, Vasovagal, Sick Sinus Syndrome.

Is NCT02954666 still recruiting?

NCT02954666 is currently completed. Last updated 20 January 2021.

Last reviewed 2021-01-20 · How we verify

NCT02954666: CardNMH2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Second Study on Cardio-neuromodulation in Humans

Completed NA Last updated 20 January 2021

What this trial tests

NA trial testing radio-frequency ablation in Cardiac Disease in 50 participants. Completed in 11 May 2020.

Timeline

10 December 2016

Primary endpoint
1 April 2020

11 May 2020

Quick facts

Lead sponsor	Imelda Hospital, Bonheiden
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	50
Start date	10 December 2016
Primary completion	1 April 2020
Estimated completion	11 May 2020
Sites	1 location across Belgium

Drugs / interventions tested

radio-frequency ablation

Conditions studied

Cardiac Disease — all drugs for Cardiac Disease →
Syncope — all drugs for Syncope →
Syncope, Vasovagal — all drugs for Syncope, Vasovagal →
Sick Sinus Syndrome — all drugs for Sick Sinus Syndrome →

Sponsor

Imelda Hospital, Bonheiden

Who can join

14 and older, any sex, with Cardiac Disease or Syncope. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Different approaches to cardio-neuroablation (CNA) to treat neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block have been published. Investigators have developed a more limited and specific approach of CNA, called cardio-neuromodulation (CardNM). This treatment is based on a tailored vagolysis of the sinoatrial node through partial ablation of the anterior right ganglionated plexus (ARGP); it is also based on an innovative anatomic strategy. The feasibility of CardNM has already been tested in our center in a limited first study in humans (CardNMH1), with a favorable outcome for the patients involved. The results of CardNMH1 have been submitted for publication. The purpose of this second study of CardNM in humans (CardNMH2) is to collect more procedural and clinical data in well-defined patient groups.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Durable Physiological Changes and Decreased Syncope Burden 12 Months After Unifocal Right-Sided Ablation Under Computed Tomographic Guidance in Patients With Neurally Mediated Syncope or Functional Sinus Node Dysfunction.
Debruyne P, Rossenbacker T, Janssens L, Collienne C, et al · · 2021 · cited 44× · PMID 33999698 · DOI 10.1161/circep.120.009747

Verify or expand the search:

Other recruiting trials for Cardiac Disease

Currently open trials in the same condition.

NCT07532174 — Efferon LPS Hemoadsorption in Cardiac Surgery Patients · NA · recruiting
NCT06294119 — Multivariate Approach to the Numerical Assessment of Cortical - Autonomic - VAscular Dynamic Interplay · NA · recruiting
NCT07274436 — The Clinical Value of Deep Learning-Based Reconstruction Techniques in Cardiac MRI Scanning · recruiting
NCT07217392 — Left Bundle Branch Area Pacing (LBBAP) PMCF Study · NA · recruiting
NCT05877755 — Validation of Multi-contrast, High-resolution Cardiac Magnetic Resonance Imaging · NA · recruiting

Other Imelda Hospital, Bonheiden trials

Trials by the same sponsor.

NCT05246813 — Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP) · recruiting
NCT04755101 — Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated Syncope · NA · recruiting
NCT04770597 — Monitors to Improve Indoor Carbon Dioxide (CO2) Concentrations in the Hospital · NA · completed
NCT02630329 — Notes Adnexectomy for Benign Pathology Compared to Laparoscopic Excision · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02954666 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Imelda Hospital, Bonheiden
Last refreshed: 20 January 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02954666.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing