NCT05242406 is a NA clinical trial of Expiratory muscle trainig in Obstructive Sleep Apnea, sponsored by Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital.

What drugs are being tested in NCT05242406?

Interventions in NCT05242406: Expiratory muscle trainig.

What condition does NCT05242406 study?

NCT05242406 studies Obstructive Sleep Apnea, Oxidative Stress, Respiratory Muscle Training.

Is NCT05242406 still recruiting?

NCT05242406 is currently completed. Last updated 14 August 2023.

Last reviewed 2023-08-14 · How we verify

NCT05242406

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of EMST Systemic Inflammation and Oxidative Stress in Patients With Moderate OSAS

Completed NA Last updated 14 August 2023

What this trial tests

NA trial testing Expiratory muscle trainig in Obstructive Sleep Apnea in 31 participants. Completed in 1 April 2023.

Timeline

1 June 2022

Primary endpoint
1 April 2023

1 April 2023

Quick facts

Lead sponsor	Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	31
Start date	1 June 2022
Primary completion	1 April 2023
Estimated completion	1 April 2023
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Expiratory muscle trainig

Conditions studied

Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →
Oxidative Stress — all drugs for Oxidative Stress →
Respiratory Muscle Training — all drugs for Respiratory Muscle Training →

Sponsor

Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital

Who can join

Adults 19 to 60, male only, with Obstructive Sleep Apnea or Oxidative Stress. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

It was aimed to investigate the effect of expiratory muscle strength training (EMST) applied at different intensities on systemic inflammation and oxidative stress in patients with moderate obstructive sleep apnea syndrome (OSAS). In the study, 32 male patients diagnosed with moderate OSAS will be included in the study. Participants will then be divided into 2 groups by block randomization. In the three-blind planned study; the first group will receive high-intensity %60 maximum expiratory pressure (MEP) EMST training, and the second group will be given low-intensity 30% of MEP, EMST training for 12 weeks. Disease-related symptoms, disease severity apnea-hypopnea index (AHI), oxidative stress index (OSI) and systemic inflammation level, exercise capacity, respiratory muscle strength, sleep quality, daytime sleepiness, and fatigue severity will be evaluated before and after the study.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Expiratory muscle strength training reduces oxidative stress and systemic inflammation in men with obstructive sleep apnea syndrome: a double-blinded, randomized parallel trial.
Erturk N, Celik A, Kahraman Yaman S, Yaman H, et al · · 2024 · cited 1× · PMID 39297486 · DOI 10.1093/sleep/zsae221

Verify or expand the search:

Other trials of Expiratory muscle trainig

Trials testing the same drug.

NCT04454242 — High and Low Intensity Expiratory Muscle Strength Training in Patients With Obstructive Sleep Apnea Syndrome · NA · completed

Other recruiting trials for Obstructive Sleep Apnea

Currently open trials in the same condition.

NCT07195253 — Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down Syndrome · recruiting
NCT07273019 — Tongue Muscular Assessment in Children With Sleep Disordered Breathing · NA · recruiting
NCT07447011 — Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea · NA · recruiting
NCT07397780 — RPMO2 Oximeter Accuracy During Sleep 1 Trial · active not recruiting
NCT06698809 — Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness · NA · recruiting

Other Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital trials

Trials by the same sponsor.

NCT04454242 — High and Low Intensity Expiratory Muscle Strength Training in Patients With Obstructive Sleep Apnea Syndrome · NA · completed
NCT04930484 — Validity and Reliability of the Turkish Version of Performance Measure for Activities of Daily Living-8 · completed
NCT04451993 — Physical Activity Level in Patients With OSAS During Covid-19 Pandemic · completed
NCT04201236 — Oropharyngeal Exercises and Inspiratory Muscle Training in Obstructive Sleep Apnea · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05242406 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital
Last refreshed: 14 August 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05242406.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing