Who is sponsoring NCT05240924?

NCT05240924 is sponsored by VA Office of Research and Development.

What drugs are being tested in NCT05240924?

Interventions in NCT05240924: Exposure and Response Prevention, Stress Management Training.

What condition does NCT05240924 study?

NCT05240924 studies Obsessive Compulsive Disorder (OCD), Comorbid Post-Traumatic Stress Disorder and OCD.

Is NCT05240924 still recruiting?

NCT05240924 is currently recruiting now. Last updated 13 November 2025.

Last reviewed 2025-11-13 · How we verify

NCT05240924

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

ERP to Improve Functioning in Veterans With OCD

Recruiting now NA Last updated 13 November 2025

What this trial tests

NA trial testing Exposure and Response Prevention in Obsessive Compulsive Disorder (OCD) in 160 participants. Currently enrolling.

Timeline

3 October 2022

Primary endpoint
31 May 2026

31 May 2026

Quick facts

Lead sponsor	VA Office of Research and Development
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	160
Start date	3 October 2022
Primary completion	31 May 2026
Estimated completion	31 May 2026
Sites	18 locations across United States

Drugs / interventions tested

Exposure and Response Prevention
Stress Management Training

Conditions studied

Obsessive Compulsive Disorder (OCD) — all drugs for Obsessive Compulsive Disorder (OCD) →
Comorbid Post-Traumatic Stress Disorder and OCD — all drugs for Comorbid Post-Traumatic Stress Disorder and OCD →

Sponsor

VA Office of Research and Development — full company profile →

Who can join

18 and older, any sex, with Obsessive Compulsive Disorder (OCD) or Comorbid Post-Traumatic Stress Disorder and OCD. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A protocol for a randomized controlled trial of exposure and response prevention for veterans with obsessive compulsive disorder.
Ponzini GT, Hundt NE, Christie IC, Chen PV, et al · · 2024 · PMID 38237674 · DOI 10.1016/j.cct.2024.107445

Verify or expand the search:

Other trials of Exposure and Response Prevention

Trials testing the same drug.

NCT07011901 — Precision Analytic Research Methods in OCD · NA · recruiting
NCT03601312 — Randomized Controlled Trial of Standard ERP and OC-Go · NA · completed
NCT03747835 — Meal-Based Exposure and Response Prevention in Anorexia Nervosa · NA · completed

Other recruiting trials for Obsessive Compulsive Disorder (OCD)

Currently open trials in the same condition.

NCT07469358 — iCBT for Adolescents Obsessive-compulsive Dissorder · NA · active not recruiting
NCT07206212 — A Lifestyle Intervention to Reduce Cardiometabolic Risk Factors in Individuals With Obsessive-compulsive Disorder · NA · recruiting
NCT07228143 — Stepped Care Treatment for Anxiety Resilience · NA · recruiting
NCT06934525 — Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings · NA · recruiting
NCT06834217 — Transcranial Direct Current Stimulation and Extinction in Obsessive Compulsive Disorder · NA · recruiting

Other VA Office of Research and Development trials

Trials by the same sponsor.

NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05240924 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
Last refreshed: 13 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05240924.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing