NCT05231096

Comparison of the Effect of Gingival Massage of Aloe-vera Gel and Sidr Honey on Chronic Periodontitis

Completed NA Last updated 25 February 2022

What this trial tests

NA trial testing Aloe-vera gel in Gingival Massage in 105 participants. Completed in 15 October 2020.

Timeline

3 September 2019

Primary endpoint
12 June 2020

15 October 2020

Quick facts

Lead sponsor	Dow University of Health Sciences
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	105
Start date	3 September 2019
Primary completion	12 June 2020
Estimated completion	15 October 2020
Sites	1 location across Pakistan

Drugs / interventions tested

• Aloe-vera gel
• sidr honey
• Scaling ans root Debridement

Conditions studied

• Gingival Massage — all drugs for Gingival Massage →
• Chronic Periodontitis — all drugs for Chronic Periodontitis →

Sponsor

Dow University of Health Sciences

Who can join

Adults 35 to 65, any sex, with Gingival Massage or Chronic Periodontitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chronic Periodontitis is an inflammatory condition and a common disease worldwide. Honey has been used in dentistry for its beneficial properties. It has been used in many oral conditions like gingivitis and periodontal diseases for its antibacterial and healing properties, on the other hand, aloe vera gel is known for its anti-inflammatory aspects, and it has been used in dentistry for its potential advantages.

Objective The main objective of the study was to find out the effects of gingival massage with aloe-vera gel and sidr honey as adjunct to non surgical therapy after one month in patients with Chronic periodontitis and to find out whether there is a difference in the efficacy of aloe-vera gel and sidr honey in reducing plaque index, gingival index, pocket depth and bleeding on probing after one month of gingival massage when used as adjunct to non-surgical therapy.

Method 105 patients with chronic periodontitis were selected in this single-blinded Randomized control clinical trial. At recruitment non-surgical therapy i-e scaling and root debridement was performed. At baseline all clinical parameters, gingival index, plaque index, bleeding on probing and pocket depths were recorded. All the participants were then randomly divided in three groups, Group A: SRD \& Gingival massage with Aloe-vera gel, Group B: SRD \& Gingival massage with Sidr honey and Group C SRD only. On 30th day of trial all the patients were re-examined for all the clinical parameters.

Statistical Analysis SPSS version 21 was used for data entry and analysis with significance level set at Ƥ \<0.05. Median, median difference and Inter Quartile ranges were reported for plaque index, gingival index, probing depth and percentages were reported for bleeding on probing. Wilcoxon Signed rank test was used for pre and post comparison. Mann Whitney test was applied for comparison between groups.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Clinical Assessment of the Efficacy of Natural Nutraceuticals in Gingival Massage Therapy: A Randomized Clinical Study.
   Khalid F, Ahmed S, Farooqui WA, Pervaiz H, et al · · 2026 · PMID 41373073 · DOI 10.1111/idh.70014
2. Comparative Efficacy of Gingival Massage of Aloe-vera gel and Sidr Honey on Gingival health: a randomized clinical trial
   Khalid F, Ahmed S, Farooqui WA, Pervaiz H, et al · · 2023 · DOI 10.21203/rs.3.rs-2441890/v1