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NCT05227859
Which is Better Piezosurgery or LLLT in Accelerating Orthodontic Tooth Movement
NA trial testing Piezocision in Class II Malocclusion in 60 participants. Completed in 26 November 2021.
28 April 2021
Quick facts
| Lead sponsor | Damascus University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 8 November 2020 |
| Primary completion | 28 April 2021 |
| Estimated completion | 26 November 2021 |
| Sites | 1 location across Syria |
Drugs / interventions tested
- Piezocision
- Low-level laser
- Conventional treatment — full drug profile →
Conditions studied
- Class II Malocclusion — all drugs for Class II Malocclusion →
Sponsor
Damascus University
Who can join
Adults 17 to 28, any sex, with Class II Malocclusion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Sixty patients requiring extraction-based treatment of the maxillary first premolars, followed by retraction of the maxillary canines, will be randomly assigned to three groups: piezocision, low-level laser therapy, and control. In each group, canine retraction will be initiated after completion of the leveling and alignment phase, using closed nickel-titanium coil springs that apply 150 g of force per side. For anchorage, a soldered transpalatal arch will be used. Pre- and post-distalization dental casts will be assessed to evaluate the rate of canine retraction, canine rotation, and anchorage loss over the follow-up period until a Class I canine relationship is achieved. Periodontal health will be assessed before and after canine retraction by evaluating the following parameters: plaque index, gingival index, bleeding index, and probing depth.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05227859
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Piezocision
Trials testing the same drug.
- NCT05656898 — Evaluation of the Levels of Pain and Discomfort and Periodontal Status Between Two Acceleration Methods of Upper Anterio · NA · completed
- NCT04338789 — Accelerated Mandibular Molar Protraction: Piezocision at the Time of Molar Protraction or Later? · NA · completed
- NCT03089996 — Evaluation of Clinical Approaches to Accelerate Orthodontic Tooth Movement · NA · completed
- NCT03782766 — Mandibular Second Molar Protraction Assisted by Piezocision · NA · completed
Other recruiting trials for Class II Malocclusion
Currently open trials in the same condition.
- NCT05684510 — Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy · NA · recruiting
- NCT07340242 — Dentoskeletal Effects of 3D-Printed Fixed Twin Block Versus MARA Appliances in Management of Skeletal Class II · NA · recruiting
- NCT07361172 — Ready-made vs. Custom-made Carriere Motion Appliance · NA · recruiting
- NCT06511219 — Maxillary Segmental Distalization Using Digitally Printed Appliances · NA · recruiting
- NCT06651944 — Invisalign® System with Mandibular Advancement · NA · recruiting
Other Damascus University trials
Trials by the same sponsor.
- NCT07532161 — Comparison Between Liquid Fibrin and Soft Laser Effects on Healing and Relapse After Lip Repositioning Surgery · NA · not yet recruiting
- NCT07515612 — The Impact of Valerian and Chamomile on Children's Anxiety in the Dental Clinic. · NA · recruiting
- NCT07272798 — Cardiac Self-Efficacy in Patients With Chronic Thromboembolic Pulmonary Hypertension · recruiting
- NCT07426523 — Effectiveness of Needle-Free Infiltration Anesthesia in Reduction of Dental Pain and Anxiety During Local Anesthesia. · NA · completed
- NCT07366788 — Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in Children · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05227859 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Damascus University
- Last refreshed: 13 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05227859.
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