NCT05217849 (MOTION) is a NA clinical trial of Tai Chi in Mild Cognitive Impairment, sponsored by University of California, San Francisco.

Who is sponsoring NCT05217849?

NCT05217849 is sponsored by University of California, San Francisco.

What drugs are being tested in NCT05217849?

Interventions in NCT05217849: Tai Chi, Preventing Loss of Independence through Exercise (PLIE), Health and Wellness Education.

What condition does NCT05217849 study?

NCT05217849 studies Mild Cognitive Impairment, Subjective Memory Decline.

Is NCT05217849 still recruiting?

NCT05217849 is currently completed. Last updated 9 February 2026.

Last reviewed 2026-02-09 · How we verify

NCT05217849: MOTION

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)

Completed NA Last updated 9 February 2026

What this trial tests

NA trial testing Tai Chi in Mild Cognitive Impairment in 77 participants. Completed in 31 December 2025.

Timeline

15 February 2022

Primary endpoint
16 July 2024

31 December 2025

Quick facts

Lead sponsor	University of California, San Francisco
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	77
Start date	15 February 2022
Primary completion	16 July 2024
Estimated completion	31 December 2025
Sites	1 location across United States

Drugs / interventions tested

Tai Chi
Preventing Loss of Independence through Exercise (PLIE)
Health and Wellness Education

Conditions studied

Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →
Subjective Memory Decline — all drugs for Subjective Memory Decline →

Sponsor

University of California, San Francisco

Who can join

55 and older, any sex, with Mild Cognitive Impairment or Subjective Memory Decline. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to compare the effects of three on-line wellness interventions for improving physical and cognitive function and brain connectivity in adults who are at least 55 years old and are experiencing symptoms of memory and/or cognitive difficulties.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION) - A randomized comparative-effectiveness study of two remotely delivered mind-body interventions for older adults with cognitive decline.
Chao LL, Barnes DE, Chesney MA, Mehling WE, et al · · 2025 · PMID 39809343 · DOI 10.1016/j.cct.2025.107811

Verify or expand the search:

Other trials of Tai Chi

Trials testing the same drug.

NCT07480174 — Effects of Tai Chi and Yoga on Flexibility, Anxiety, and Sleep Quality in Women · NA · recruiting
NCT07341802 — Pilot Feasibility Study of a Fall Prevention Exercise Programme for Community-dwelling Older Adults in Nanchang, China · NA · recruiting
NCT07461987 — Tai Chi and Square-Stepping Exercises in Women With Multiple Sclerosis · NA · recruiting
NCT07512739 — A Sitting Tai Chi Programme for Chronic Stroke Survivors With Post-stroke Cognitive Impairment · NA · recruiting
NCT07113444 — Acute Effect of Tai Chi Versus Moderate-Intensity Combined Exercise on Cardiovascular, Metabolic, and Cardiac Autonomic · NA · not yet recruiting

Other recruiting trials for Mild Cognitive Impairment

Currently open trials in the same condition.

NCT05791994 — EVASION: Effect of VisuAl Stimulation on attentION · NA · recruiting
NCT07169630 — PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) · Phase 1 · recruiting
NCT07220694 — Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairmen · NA · recruiting
NCT06983769 — CPAP vs MAD for OSA in Patients With Cognitive Impairment. A Randomized Clinical Trial · NA · recruiting
NCT07318038 — The Use of Rhythmic Light Therapy in Mild Cognitive Impairment · NA · recruiting

Other University of California, San Francisco trials

Trials by the same sponsor.

NCT05284773 — Screening for Acute Malnutrition · NA · withdrawn
NCT04634851 — Video Home Visits for Dietary Counselling · NA · not yet recruiting
NCT06065670 — Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a M · Phase 1, PHASE2 · not yet recruiting
NCT07534098 — Intervention for Hearing Health Among Native Americans · NA · not yet recruiting
NCT06960421 — Exercise-based Frailty Intervention in Lung Transplantation (XFIT) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05217849 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, San Francisco
Last refreshed: 9 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05217849.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing