Last reviewed · How we verify
NCT05215431
Periodontal Health Status in Patients with Systemic Sclerosis
NA trial testing periodontal examination's, determination of salivary antioxidants and cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid, Non-surgical therapy of periodontitis in Systemic Sclerosis in 60 participants. Status unknown.
1 November 2024
Quick facts
| Lead sponsor | University of Belgrade |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 5 February 2019 |
| Primary completion | 1 November 2024 |
| Estimated completion | 1 November 2024 |
| Sites | 1 location across Serbia |
Drugs / interventions tested
- periodontal examination's, determination of salivary antioxidants and cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid, Non-surgical therapy of periodontitis
- Activity of antioxidants in unstimulated saliva (GPX, SOD, UA)
- Total cytokine levels (VEGF, TGF-β, Il-17) in gingival crevicular fluid
- Periodontal treatment
Conditions studied
- Systemic Sclerosis — all drugs for Systemic Sclerosis →
- Periodontitis — all drugs for Periodontitis →
Sponsor
University of Belgrade
Who can join
Eligibility, any sex, with Systemic Sclerosis or Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the research will be to evaluate the effects of NSPT on clinical periodontal parameters, level of antioxidants in unstimulated saliva and the levels of biomarkers (VEGF, TGF-β, IL-17) in the GCF in SSc patients in comparison with systemically healthy controls. Twenty systemic sclerosis patients with periodontitis (SS group) and twenty systemically healthy periodontitis patients (P group) will be enrolled in the present study. The results may indicate higher periodontal destruction and antioxidant perturbations in unstimulated saliva of systemic sclerosis patients with periodontitis compared to systemically healthy periodontitis patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis.
Sredojevic SI, Dolijanovic SP, Dozic I, Pficer JK, et al · · 2023 · cited 2× · PMID 37138665 · DOI 10.1155/2023/7886272
Verify or expand the search:
- PubMed search for NCT05215431
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Systemic Sclerosis
Currently open trials in the same condition.
- NCT07335562 — A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versu · Phase 3 · recruiting
- NCT06947473 — Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH. · Phase 1, PHASE2 · recruiting
- NCT07047690 — A Study of Nemolizumab for the Treatment of Adults With Systemic Sclerosis · Phase 2 · recruiting
- NCT07246096 — Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Rel · EARLY_PHASE1 · recruiting
- NCT07295847 — A Study of AZD0120 in Autoimmune Diseases · Phase 1 · recruiting
Other University of Belgrade trials
Trials by the same sponsor.
- NCT07414433 — Validation of Blood-Based Biomarkers in TACE-Treated Hepatocellular Carcinoma · not yet recruiting
- NCT07337759 — Fetus Programming and Long Active Outcomes, Interaction Between Mother, Placenta and Fetus in Perinatal and Methabolic D · completed
- NCT06885983 — Healing After Augmentation of Alveolar Ridge Using Collagen Membrane · NA · enrolling by invitation
- NCT07378709 — Exploratory Blood-Based Biomarkers in TACE-Treated Hepatocellular Carcinoma · recruiting
- NCT06349382 — CArbohydrate Loading in Aortic Surgery · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05215431 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Belgrade
- Last refreshed: 19 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05215431.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing