NCT05208216 (ENSARIA) is a NA clinical trial of Geko device in Critical Illness, sponsored by Manchester University NHS Foundation Trust.

Who is sponsoring NCT05208216?

NCT05208216 is sponsored by Manchester University NHS Foundation Trust.

What drugs are being tested in NCT05208216?

Interventions in NCT05208216: Geko device, Flowtron DVT.

What condition does NCT05208216 study?

NCT05208216 studies Critical Illness, Sepsis, Acute Illness, Venous Thromboembolism.

Is NCT05208216 still recruiting?

NCT05208216 is currently completed. Last updated 25 September 2025.

Last reviewed 2025-09-25 · How we verify

NCT05208216: ENSARIA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Neuromuscular Stimulation Versus Intermittent Compression for Venous Thromboembolism Prophylaxis in Critical Care

Completed NA Last updated 25 September 2025

What this trial tests

NA trial testing Geko device in Critical Illness in 40 participants. Completed in 1 May 2024.

Timeline

1 November 2022

Primary endpoint
1 May 2024

1 May 2024

Quick facts

Lead sponsor	Manchester University NHS Foundation Trust
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	40
Start date	1 November 2022
Primary completion	1 May 2024
Estimated completion	1 May 2024
Sites	1 location across United Kingdom

Drugs / interventions tested

Geko device
Flowtron DVT

Conditions studied

Critical Illness — all drugs for Critical Illness →
Sepsis — all drugs for Sepsis →
Acute Illness — all drugs for Acute Illness →
Venous Thromboembolism — all drugs for Venous Thromboembolism →

Sponsor

Manchester University NHS Foundation Trust

Who can join

18 and older, any sex, with Critical Illness or Sepsis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this prospective, randomised, open-label, parallel group, feasibility trial; the investigators will objectively assess whether it is feasible to apply the Geko device to critically ill adults for the prevention of venous thromboembolism (VTE) compared to usual care with intermittent pneumatic compression devices (IPCs).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

ESICM LIVES 2024. Barcelona, Spain. 5–9 October 2024.
· 2024 · cited 1× · PMID 39361093 · DOI 10.1186/s40635-024-00658-z
Electronic neuromuscular stimulation versus intermittent pneumatic compression devices for the prevention of venous thromboembolic disease in critically ill adults: a randomised feasibility study
Fowler N, Paripoorani D, Edlin H, Ramakrishnan V, et al · · 2026 · DOI 10.21203/rs.3.rs-9074085/v1

Verify or expand the search:

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Other Manchester University NHS Foundation Trust trials

Trials by the same sponsor.

NCT07057284 — DENTOFACIAL-PBT Stage 2 - Feasibility Study · enrolling by invitation
NCT06972238 — Glucose Levels in Acute Pancreatitis and the Impact of Insulin Depletion and Bacterial Endotoxaemia · not yet recruiting
NCT06681545 — Exploring the Lived Experience of Young Adults With Severe Asthma · recruiting
NCT07049263 — Disparities In Access to the Northwest Ambulance Service During Pregnancy, Birth and Postpartum Period and Its Associati · active not recruiting
NCT06561334 — Spasmodic Dysphonia Interviews · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05208216 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Manchester University NHS Foundation Trust
Last refreshed: 25 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05208216.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing