NCT05196984 is a NA clinical trial of GENUS device (Active Settings) in Down Syndrome, sponsored by Massachusetts Institute of Technology.

Who is sponsoring NCT05196984?

NCT05196984 is sponsored by Massachusetts Institute of Technology.

What drugs are being tested in NCT05196984?

Interventions in NCT05196984: GENUS device (Active Settings), GENUS device (Sham Settings).

What condition does NCT05196984 study?

NCT05196984 studies Down Syndrome.

Is NCT05196984 still recruiting?

NCT05196984 is currently recruiting now. Last updated 31 March 2026.

Last reviewed 2026-03-31 · How we verify

NCT05196984

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Gamma Frequency Stimulation in Individuals With Down Syndrome

Recruiting now NA Last updated 31 March 2026

What this trial tests

NA trial testing GENUS device (Active Settings) in Down Syndrome in 60 participants. Currently enrolling.

Timeline

6 December 2021

Primary endpoint
31 December 2026

31 December 2026

Quick facts

Lead sponsor	Massachusetts Institute of Technology
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	supportive care
Enrollment	60
Start date	6 December 2021
Primary completion	31 December 2026
Estimated completion	31 December 2026
Sites	1 location across United States

Drugs / interventions tested

GENUS device (Active Settings)
GENUS device (Sham Settings)

Conditions studied

Down Syndrome — all drugs for Down Syndrome →

Sponsor

Massachusetts Institute of Technology

Who can join

Adults 25 to 65, any sex, with Down Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Down Syndrome (DS) is characterized by an additional copy of chromosome 21, which also increases risk of Alzheimer's Disease (AD). The investigators' lab found a non-invasive way to remove toxic proteins from the brain in AD mouse models. Remarkably, treated mice also have improved memory on behavioral testing. The investigators then translated this non-invasive method, which uses light and sound to stimulate the brain, to be used in mild Alzheimer's patients and cognitively normal adults. The investigators have also translated this research into a vibrating speaker device to study tactile vibration to stimulate the brain as well. For the present study, 30 participants with Down Syndrome and 30 cognitively normal adult controls will be recruited, and the investigators will assess their brain waves with electroencephalogram (EEG) during light, sound, and tactile stimulation. The investigators will also test for safety, feasibility, and cognitive performance before and after a 30-60 minute session of light and sound stimulation to optimize the stimulation devices for use in the DS population.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Audiovisual gamma stimulation for the treatment of neurodegeneration.
Blanco-Duque C, Chan D, Kahn MC, Murdock MH, et al · · 2024 · cited 42× · PMID 38115692 · DOI 10.1111/joim.13755

Verify or expand the search:

Other trials of GENUS device (Active Settings)

Trials testing the same drug.

NCT05655195 — Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy · NA · recruiting
NCT04055376 — Daily Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease · NA · active not recruiting
NCT04042922 — High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease · NA · active not recruiting

Other recruiting trials for Down Syndrome

Currently open trials in the same condition.

NCT07416201 — Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy · recruiting
NCT07484464 — Effects of the Otago Exercise Program on Balance, Endurance, and Motor Coordination in Children With Down Syndrome · NA · recruiting
NCT07428863 — Effects of Jump Rope on Navicular Drop in Down Syndrome · NA · recruiting
NCT07260136 — Cervical Spine Abnormalities in Down Syndrome · active not recruiting
NCT07248449 — Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises · NA · recruiting

Other Massachusetts Institute of Technology trials

Trials by the same sponsor.

NCT07508722 — Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans · NA · not yet recruiting
NCT07204912 — Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks · NA · recruiting
NCT06887569 — Using Financial Incentives and Screening to Increase Engagement With Mental Health Services Among College Students in Ch · NA · completed
NCT06725511 — Wellness Program Outreach and Effectiveness · NA · recruiting
NCT05964855 — Comparison of Various Prosthetic Foot-Ankle Mechanisms · NA · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05196984 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Massachusetts Institute of Technology
Last refreshed: 31 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05196984.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing