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NCT05964855
Comparison of Various Prosthetic Foot-Ankle Mechanisms
NA trial testing MIT Variable Stiffness Prosthesis in Transtibial Amputation - Unilateral in 10 participants. Enrolling by invitation.
1 September 2025
Quick facts
| Lead sponsor | Massachusetts Institute of Technology |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 10 |
| Start date | 28 July 2023 |
| Primary completion | 1 September 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- MIT Variable Stiffness Prosthesis
- MIT Variable Equilibrium Angle Prosthesis
- MIT Sliding Beam Passive Prosthesis
- Ossur Pro-flex XC
- Blatchford Elan Variable-Dampening Prosthesis
Conditions studied
- Transtibial Amputation - Unilateral — all drugs for Transtibial Amputation - Unilateral →
Sponsor
Massachusetts Institute of Technology
Who can join
Adults 18 to 65, any sex, with Transtibial Amputation - Unilateral. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In summary, subjects will be asked to wear a number of sensors and use different ankle-foot prostheses in place of their customary prosthesis. Data will be collected from the wearable sensors, VICON motion capture system, video cameras, and force sensors in the ground as they walk on level-ground, on a treadmill, and on stairs. The controller of any powered prosthesis will be electronically adjusted between trials or while the subject walks to determine how their gait changes in response to these changes. Trials will also be conducted with a standard passive prosthesis that would be prescribed for a person of similar height and weight.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05964855
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other recruiting trials for Transtibial Amputation - Unilateral
Currently open trials in the same condition.
- NCT07263945 — Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes · Phase 1 · recruiting
Other Massachusetts Institute of Technology trials
Trials by the same sponsor.
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- NCT07204912 — Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks · NA · recruiting
- NCT06887569 — Using Financial Incentives and Screening to Increase Engagement With Mental Health Services Among College Students in Ch · NA · completed
- NCT06725511 — Wellness Program Outreach and Effectiveness · NA · recruiting
- NCT06011837 — Effects of Altered Auditory Feedback on Speech Fluency · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05964855 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Massachusetts Institute of Technology
- Last refreshed: 13 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05964855.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing