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NCT05178212: AW-PP_Covid
Characteristics and Outcomes of Patients With COVID-19 Treated With HFNO and Prone Positioning
trial in COVID-19 in 600 participants. Completed in 31 December 2022.
30 December 2021
Quick facts
| Lead sponsor | Hospital Privado de Comunidad de Mar del Plata |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 600 |
| Start date | 15 April 2020 |
| Primary completion | 30 December 2021 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across Argentina |
Conditions studied
- COVID-19 — all drugs for COVID-19 →
- Respiratory Failure — all drugs for Respiratory Failure →
- Prone Position — all drugs for Prone Position →
- Endotracheal Intubation — all drugs for Endotracheal Intubation →
Sponsor
Hospital Privado de Comunidad de Mar del Plata
Who can join
18 and older, any sex, with COVID-19 or Respiratory Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A subset of patients with COVID-19 develops acute respiratory failure and acute respiratory distress syndrome (ARDS) (1). The use of invasive mechanical ventilation for the treatment of these conditions is associated with high mortality rates (2,3). The use of high-flow nasal oxygen therapy (HFNO) and awake prone position (AW-PP) could to decrease the need for endotracheal intubation and other adverse clinical outcomes (4-6). The aim of this study is to evaluate the clinical results of the simultaneous application of high-flow nasal oxygen therapy HFNO and awake-prone position in a cohort of patients with severe respiratory failure secondary to COVID-19 on relevant clinical outcomes, and to assess risk factors of treatment failure defined as requirement of invasive mechanical ventilation.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Effectiveness of bundle of care on tolerance of awake-prone positioning in patients with acute respiratory failure. A multicenter observational study.
Olmos M, Fuentes N, Busico M, Gallardo A, et al · · 2025 · cited 7× · PMID 39961842 · DOI 10.1007/s00134-025-07804-5 -
Comparison of the effectiveness of awake-prone positioning and high-flow nasal oxygen in patients with COVID-19-related acute respiratory failure between different waves.
Esperatti M, Olmos M, Busico M, Gallardo A, et al · · 2024 · cited 3× · PMID 39442133 · DOI 10.62675/2965-2774.20240065-en -
A predictive model for early intubation in patients with COVID-19-induced acute hypoxemic respiratory failure under awake prone position.
Morales-Quinteros L, Fuentes NA, Muriel A, Olmos M, et al · · 2025 · PMID 41284115 · DOI 10.1186/s13613-025-01602-4
Verify or expand the search:
- PubMed search for NCT05178212
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for COVID-19
Currently open trials in the same condition.
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- NCT07300839 — A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age · Phase 3 · active not recruiting
- NCT07221162 — A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes · Phase 1 · recruiting
- NCT07215520 — Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults · Phase 2 · recruiting
- NCT07222384 — A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That A · Phase 3 · active not recruiting
Other Hospital Privado de Comunidad de Mar del Plata trials
Trials by the same sponsor.
- NCT06535386 — Polyuria Associated With Dexmedetomidine in Operating Room · not yet recruiting
- NCT06141681 — Evaluation of Microcirculation With Photoplethysmography (Pulse Oximetry) in Healthy Volunteers and Ventilated Patients · unknown
- NCT05873998 — Detecting Lung's Closing Pressure by Capnography · completed
- NCT05512611 — Photoplethysmography for Diagnose Incipient Hypovolemia · completed
- NCT04183309 — Effects of Pneumoperitoneum on Dynamic Alveolar Stress-strain in Anesthetized Pediatric Patients · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05178212 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Privado de Comunidad de Mar del Plata
- Last refreshed: 27 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05178212.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing