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NCT04183309
Effects of Pneumoperitoneum on Dynamic Alveolar Stress-strain in Anesthetized Pediatric Patients
trial testing Measure the transpulmonary pressure in pediatric patients in Atelectasis in 20 participants. Completed in 29 July 2022.
29 July 2022
Quick facts
| Lead sponsor | Hospital Privado de Comunidad de Mar del Plata |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 6 January 2020 |
| Primary completion | 29 July 2022 |
| Estimated completion | 29 July 2022 |
| Sites | 1 location across Argentina |
Drugs / interventions tested
- Measure the transpulmonary pressure in pediatric patients
Conditions studied
- Atelectasis — all drugs for Atelectasis →
Sponsor
Hospital Privado de Comunidad de Mar del Plata
Who can join
Adults 3 to 7, any sex, with Atelectasis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
General anesthesia is associated with loss of pulmonary functional residual capacity and consequent developement of atelectasis and closure of the small airway. Infants and young children are more susceptible to this lung collapse due to their small functional residual capacity. Mechanical ventilation in a lung with reduced functional residual capacity and atelectasis increased the dynamic alveolar stress-strain inducing a local inflammatory response in atelectatic lungs areas know as ventilatory induced-lung injury (VILI). This phenomenon may appear even in healthy patients undergoing general anesthesia and predisposes children to hypoxemic episodes that can persist in the early postoperative period. During laparoscopy, pneumoperitoneum may aggravate the reduction of functional residual capacity as it generates a further increase in intra-abdominal pressure. The increase in alveolar stress-strain cloud be reduced during pneumoperitoneum in theory, if normal functional residual capacity is restored and the transpulmonary pression is reached at the end of expiration of 0-1 cmH2O.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04183309
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Related trials
Other recruiting trials for Atelectasis
Currently open trials in the same condition.
- NCT07451405 — The Effect of Oscillation and Lung Expansion (OLE) Therapy in Prolonged Mechanical Ventilated Patients With Atelectasis · NA · recruiting
- NCT07211529 — Intraoperative Paravertebral Block and Postoperative Complications · NA · recruiting
- NCT06662630 — Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients · NA · recruiting
- NCT06296173 — Open Lung Protective Extubation Following General Anesthesia · NA · recruiting
- NCT06171477 — Regional Distribution of Ventilation at Different Respiratory Rates · NA · recruiting
Other Hospital Privado de Comunidad de Mar del Plata trials
Trials by the same sponsor.
- NCT06535386 — Polyuria Associated With Dexmedetomidine in Operating Room · not yet recruiting
- NCT06141681 — Evaluation of Microcirculation With Photoplethysmography (Pulse Oximetry) in Healthy Volunteers and Ventilated Patients · unknown
- NCT05873998 — Detecting Lung's Closing Pressure by Capnography · completed
- NCT05512611 — Photoplethysmography for Diagnose Incipient Hypovolemia · completed
- NCT05178212 — Characteristics and Outcomes of Patients With COVID-19 Treated With HFNO and Prone Positioning · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04183309 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Privado de Comunidad de Mar del Plata
- Last refreshed: 29 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04183309.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing