NCT05172089 (DFUBiofilm) is a clinical trial in Chronic Wounds, sponsored by University of Pittsburgh.

Who is sponsoring NCT05172089?

NCT05172089 is sponsored by University of Pittsburgh.

What condition does NCT05172089 study?

NCT05172089 studies Chronic Wounds, Biofilm Infection, Trans-epidermal Water Loss (TEWL), Diabetic Foot, Diabetic Foot Infection.

Is NCT05172089 still recruiting?

NCT05172089 is currently recruiting now. Last updated 18 March 2026.

Last reviewed 2026-03-18 · How we verify

NCT05172089: DFUBiofilm

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence

Recruiting now Last updated 18 March 2026

What this trial tests

trial in Chronic Wounds in 405 participants. Currently enrolling.

Timeline

2 April 2024

Primary endpoint
27 June 2028

27 June 2029

Quick facts

Lead sponsor	University of Pittsburgh
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	405
Start date	2 April 2024
Primary completion	27 June 2028
Estimated completion	27 June 2029
Sites	2 locations across United States

Conditions studied

Chronic Wounds — all drugs for Chronic Wounds →
Biofilm Infection — all drugs for Biofilm Infection →
Trans-epidermal Water Loss (TEWL) — all drugs for Trans-epidermal Water Loss (TEWL) →
Diabetic Foot — all drugs for Diabetic Foot →

Sponsor

University of Pittsburgh

Who can join

18 and older, any sex, with Chronic Wounds or Biofilm Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This work is based on DFU patients, seeks to conduct a fully powered clinical study testing i) If DFU with a history of biofilm infection closes with deficient barrier function. ii) whether such functionally deficient wound closure, manifested as high TEWL, is associated with greater wound recurrence. The primary parent study will also address molecular mechanisms implicated in biofilm-induced loss of skin epithelial barrier integrity in DFU patients.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Current Insights into miRNA and lncRNA Dysregulation in Diabetes: Signal Transduction, Clinical Trials and Biomarker Discovery.
Pandey A, Ajgaonkar S, Jadhav N, Saha P, et al · · 2022 · cited 14× · PMID 36297381 · DOI 10.3390/ph15101269
Clinical Measurement of Transepidermal Water Loss.
Kundu D, Jayaraman A, Sen CK. · · 2026 · cited 4× · PMID 40476522 · DOI 10.1089/wound.2024.0148

Verify or expand the search:

Other recruiting trials for Chronic Wounds

Currently open trials in the same condition.

NCT06424561 — The Influence of Systematic Psychological Intervention on Patients About VSD Drainage Surgery · NA · recruiting
NCT06939673 — Study of Miro3D Wound Matrix for Healing Wounds and Ulcers in Outpatient Care · NA · recruiting
NCT03793062 — Genetic and Epigenetic Basis of Chronic Wounds · recruiting

Other University of Pittsburgh trials

Trials by the same sponsor.

NCT05601206 — Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · NA · not yet recruiting
NCT06652815 — Cognition, Metacognition, and Stigma in Patients With Suicidal Ideation · not yet recruiting
NCT06474286 — Prucalopride for Cognitive Functioning in Schizophrenia · NA · not yet recruiting
NCT06488469 — Behavioural Problems and Cognition in Children With Hypoglycemia Unawareness in Type-1 Diabetes Mellitus · NA · not yet recruiting
NCT06652802 — Effectiveness of Nurse-Conducted Brief Intervention (NCBI) Supplemented With Mobile for Preventing Alcohol Use Disorders · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05172089 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pittsburgh
Last refreshed: 18 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05172089.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing