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NCT05167201
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
NA trial testing Nasal High Flow in Chronic Hypercapnic Respiratory Failure in 54 participants. Status unknown.
26 January 2024
Quick facts
| Lead sponsor | Royal Free Hospital NHS Foundation Trust |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 54 |
| Start date | 28 March 2022 |
| Primary completion | 26 January 2024 |
| Estimated completion | 26 January 2024 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Nasal High Flow
Conditions studied
- Chronic Hypercapnic Respiratory Failure — all drugs for Chronic Hypercapnic Respiratory Failure →
- Chronic Obstructive Pulmonary Disease — all drugs for Chronic Obstructive Pulmonary Disease →
- Obesity Hypoventilation Syndrome (OHS) — all drugs for Obesity Hypoventilation Syndrome (OHS) →
- Nasal High Flow — all drugs for Nasal High Flow →
Sponsor
Royal Free Hospital NHS Foundation Trust
Who can join
18 and older, any sex, with Chronic Hypercapnic Respiratory Failure or Chronic Obstructive Pulmonary Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality. The availability and effectiveness of domiciliary Non-invasive ventilation (NIV) treatment (when indicated) is key as this treatment can improve quality of life and reduce health-care costs from associated burden of disease. The emerging obesity epidemic means that there is now increased home mechanical ventilation set-ups in patients with obesity related respiratory failure (ORRF), yet there are no alternative treatments for patients struggling with domiciliary NIV. Domiciliary NHF has been shown to improve health related quality of life in stable CHRF in patients with COPD and improve cost effectiveness yet there are no current studies looking at the use of domiciliary NHF and its outcomes in ORRF. The study aims to deliver a pre and post intervention study evaluating patient reported and clinical outcomes in patients using NHF over twelve weeks, who have either COPD or OHS and have been unable to use domiciliary NIV. The study wishes to address key outcomes such as quality of life, clinical effectiveness, compliance and acceptability with the use of domiciliary NHF in both of these patient populations.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05167201
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Related trials
Other trials of Nasal High Flow
Trials testing the same drug.
- NCT03964376 — Nasal High Flow Therapy in Surgical Patients with Unrecognized Obstructive Sleep Apnea · NA · completed
- NCT03466385 — NHF vs NIV in Patients With Acute Exacerbation of COPD · NA · unknown
- NCT02230020 — Efficacy of High Flow Therapy in COPD At Home · terminated
Other Royal Free Hospital NHS Foundation Trust trials
Trials by the same sponsor.
- NCT06484478 — A Real-world Wearables Study in Fabry Disease. · completed
- NCT06084052 — Path Active Multicentre Randomised Controlled Trial (Previous Pilot: Path Active; Safety and Tolerability Study) · NA · recruiting
- NCT07392710 — Clinical Evaluation of the Nova Max Pro StatSensor Device · NA · completed
- NCT05189600 — Can Waveform and Flow Traces From Mechanical Insuflattion:Exsufflation (MI:E) be Used to Identify Laryngeal Responses to · recruiting
- NCT04968704 — Computer Modelling to Plan Surgical Reconstruction · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05167201 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Royal Free Hospital NHS Foundation Trust
- Last refreshed: 14 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05167201.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing