NCT05164328 (Pro@Heart) is a clinical trial of No intervention in Athlete Heart, sponsored by Universitaire Ziekenhuizen KU Leuven.

Who is sponsoring NCT05164328?

NCT05164328 is sponsored by Universitaire Ziekenhuizen KU Leuven.

What drugs are being tested in NCT05164328?

Interventions in NCT05164328: No intervention.

What condition does NCT05164328 study?

NCT05164328 studies Athlete Heart.

Is NCT05164328 still recruiting?

NCT05164328 is currently recruiting now. Last updated 20 December 2021.

Last reviewed 2021-12-20 · How we verify

NCT05164328: Pro@Heart

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prospective Athlete's Heart Study

Recruiting now Last updated 20 December 2021

What this trial tests

trial testing No intervention in Athlete Heart in 450 participants. Currently enrolling.

Timeline

23 June 2015

Primary endpoint
23 June 2035

23 June 2040

Quick facts

Lead sponsor	Universitaire Ziekenhuizen KU Leuven
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	450
Start date	23 June 2015
Primary completion	23 June 2035
Estimated completion	23 June 2040
Sites	4 locations across Belgium, Australia

Drugs / interventions tested

No intervention

Conditions studied

Athlete Heart — all drugs for Athlete Heart →

Sponsor

Universitaire Ziekenhuizen KU Leuven — full company profile →

Who can join

Adults 14 to 23, any sex, with Athlete Heart. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Rationale and design of the PROspective ATHletic Heart (Pro@Heart) study: long-term assessment of the determinants of cardiac remodelling and its clinical consequences in endurance athletes.
De Bosscher R, Dausin C, Janssens K, Bogaert J, et al · · 2022 · cited 27× · PMID 35368514 · DOI 10.1136/bmjsem-2022-001309
Blood pressure response to graded bicycle exercise in males and females across the age and fitness spectrum.
Janssens K, Foulkes SJ, Mitchell AM, Dausin C, et al · · 2025 · cited 13× · PMID 39116385 · DOI 10.1093/eurjpc/zwae262
Bradycardia in Athletes: Prevalence, Mechanisms, and Risks.
D'Ambrosio P, De Paepe J, Spencer LW, Ohanian M, et al · · 2026 · cited 1× · PMID 41410046 · DOI 10.1161/circulationaha.125.076170
Racial and Gender Differences in Cardiorespiratory Fitness and Atrial Fibrillation.
Czulada E, Shah SA, Tsimploulis A. · · 2024 · PMID 39139428 · DOI 10.31083/j.rcm2507261

Verify or expand the search:

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Other recruiting trials for Athlete Heart

Currently open trials in the same condition.

NCT07363993 — Interaction Between Intraventricular Flow and Cardiac Mechanics Using 3D Echocardiography in Athletes and Sedentary Subj · recruiting
NCT06859827 — Role of CMR-FT in Assessment of HCM and Athlete's Heart. · active not recruiting
NCT06518252 — Risk of Sudden Cardiac Death in UN Athletes · recruiting

Other Universitaire Ziekenhuizen KU Leuven trials

Trials by the same sponsor.

NCT06831955 — LifEStyle Intervention to Enhance Efficacy of Neoadjuvant Therapy in Patients With Triple Negative Breast Cancer · Phase 2 · recruiting
NCT07356505 — Efficacy and Safety of Micra AV2 Transcatheter Pacing System · NA · recruiting
NCT07286968 — Gastro-Intestinal Digestion and Physiology After Bariatric Surgery · recruiting
NCT06962137 — Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer · Phase 2 · recruiting
NCT07270536 — Accelerated Pacing and Cardiac Filling Pressures During Exercise in Patients With Heart Failure With Preserved Ejection · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05164328 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universitaire Ziekenhuizen KU Leuven
Last refreshed: 20 December 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05164328.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing