NCT05162924 is a NA clinical trial of Spinal Manipulation in Chronic Low-back Pain, sponsored by Real Centro Universitario Maria Cristina.

Who is sponsoring NCT05162924?

NCT05162924 is sponsored by Real Centro Universitario Maria Cristina.

What drugs are being tested in NCT05162924?

Interventions in NCT05162924: Spinal Manipulation, Placebo.

What condition does NCT05162924 study?

NCT05162924 studies Chronic Low-back Pain.

Is NCT05162924 still recruiting?

NCT05162924 is currently completed. Last updated 25 January 2023.

Last reviewed 2023-01-25 · How we verify

NCT05162924

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Mechanisms of Chiropractic Spinal Manipulation for Chronic Low Back Pain

Completed NA Last updated 25 January 2023

What this trial tests

NA trial testing Spinal Manipulation in Chronic Low-back Pain in 147 participants. Completed in 15 January 2023.

Timeline

17 December 2021

Primary endpoint
30 December 2022

15 January 2023

Quick facts

Lead sponsor	Real Centro Universitario Maria Cristina
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	147
Start date	17 December 2021
Primary completion	30 December 2022
Estimated completion	15 January 2023
Sites	1 location across Spain

Drugs / interventions tested

Spinal Manipulation
Placebo

Conditions studied

Chronic Low-back Pain — all drugs for Chronic Low-back Pain →

Sponsor

Real Centro Universitario Maria Cristina

Who can join

Adults 18 to 70, any sex, with Chronic Low-back Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a mechanistic randomized controlled trial on the effects of chiropractic spinal manipulative therapy on patients with chronic low back pain. It is designed as a mechanistic trial, in which the main objective is to identify which variables related to central sensitization can help predict the response to spinal manipulation, and the evolution of which of these variables can help explain clinical changes in chronic low back pain patients receiving spinal manipulative therapy.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Reduction of Chronic Primary Low Back Pain by Spinal Manipulative Therapy is Accompanied by Decreases in Segmental Mechanical Hyperalgesia and Pain Catastrophizing: A Randomized Placebo-controlled Dual-blind Mixed Experimental Trial.
Gevers-Montoro C, Romero-Santiago B, Medina-García I, Larranaga-Arzamendi B, et al · · 2024 · cited 7× · PMID 38369221 · DOI 10.1016/j.jpain.2024.02.014
Mechanisms of chiropractic spinal manipulative therapy for patients with chronic primary low back pain: protocol for a mechanistic randomised placebo-controlled trial.
Gevers-Montoro C, Ortega-De Mues A, Piché M. · · 2023 · cited 3× · PMID 36764718 · DOI 10.1136/bmjopen-2022-065999

Verify or expand the search:

Other trials of Spinal Manipulation

Trials testing the same drug.

NCT06946979 — Clinical Study on the Use of Massage to Reconstruct the Function of Lumbar Stabilizer Muscles and Improve the "Muscle an · NA · not yet recruiting
NCT07032623 — Neuromuscular Effects of Spinal Manipulation in Individuals Following Anterior Cruciate Ligament Reconstruction · NA · completed
NCT06576739 — B Vitamin Supplementation to Chiropractic Management of Chronic LBP: Pilot Clinical Trial (VCLBP) · NA · not yet recruiting
NCT06606795 — The Effects of Cervical and Thoracic Manipulation Therapy Applied to Weightlifting Athletes · NA · not yet recruiting
NCT06673537 — Spinal Manipulation For Menstrual Symptoms and Sleep in Individuals With Primary Dysmenorrhea · NA · completed

Other recruiting trials for Chronic Low-back Pain

Currently open trials in the same condition.

NCT06891625 — Movement Performance in Persons With Chronic Back Pain · NA · recruiting
NCT06568198 — Modulation Effect of tACS on Chronic Low Back Pain · Phase 2 · recruiting
NCT06825390 — AuriculoTherapy NeuroImaging · NA · recruiting
NCT04824248 — Weight Reduction in CLBP · NA · recruiting
NCT07055802 — Effects Of Inversion Table Therapy Vs MT On Pain And Lumbar Flexibility In Patients With Chronic Low Back Pain · NA · active not recruiting

Other Real Centro Universitario Maria Cristina trials

Trials by the same sponsor.

NCT05240547 — Chiropractic Spinal Manipulation for Headache · NA · unknown
NCT04666779 — Access to Chiropractic Care During the COVID-19 Pandemic · completed
NCT04573361 — Access to Chiropractic Care During the COVID-19 Healthcare Emergency in Spain · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05162924 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Real Centro Universitario Maria Cristina
Last refreshed: 25 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05162924.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing